vitamin D deficiency

Vitamin D deficiency risk to 84 % Indians: report

Changing lifestyle, increasingly odd-working hours and limited outdoor activities are leaving a bad impact on human health as 84 per cent of the country’s population was found vitamin D deficient, a recent study said here on Monday.

“In the face of present-day lifestyles, dominated by ungodly working hours and limited outdoor activities, inherent vitamin D deficiency is increasingly becoming an eyesore among a large number of people. (There is) Vitamin D deficiency risk to 84 per cent of Indians,” SRL Diagnostics said in its report.

The human body’s ideal dose of vitamin D ranges between 1,000 and 2,000 IU (International Units) per day.

“Vitamin D deficiency was found to be prevalent in around 69 per cent of the population, while 15 per cent more were found to be vitamin D insufficient, thus making around 84 per cent of Indians risk-prone to this, the study said.

The report pointed out that skin exposure to the sun is natural, intended, and most effective source of vitamin D, yet the most neglected. Tests that estimate the level of vitamin D have become increasingly common, pan-Indian.

Testing for vitamin D deficiency has been known to protect a majority of the Indian population from joint pains, muscle weakness, cardiovascular disorders and other more serious problems that could be permanently detrimental to one’s health.

While research on the impact of vitamin D on ailments is ongoing, doctors believe it is clearly associated with diabetes, high blood pressure, bone weakness, nerve-related disorders and obesity.

Doctors also point out that vitamin D directly benefits patients with diabetes and cardiovascular ailments. A sizable body of evidence proves the link between vitamin D and people with diabetes and heart ailments.

After pregnancy, women are at a higher risk of developing osteoporosis due to high demands of calcium and vitamin D, it added.

There are diagnostic tests to determine vitamin D levels in the body. It is extremely essential to keep a check on the levels of deficiency in the body as it helps retain calcium,” SRL Diagnostics President-Research & Innovation, Dr B R Das said.

“Sufficient vitamin D levels assist the body in reducing bad cholesterol and increasing good cholesterol, besides helping in the essential repair and maintenance activities in the body. It is directly linked to knee pains and osteoporosis,” Das said.

The study reveals that the differences between deficiency and insufficiency are conspicuous. Vitamin D deficiency manifests itself as a bone disease, which is mostly either rickets or osteomalacia. Whereas insufficiency may be associated with milder disease outcomes, including muscle weakness and fatigue.

Another outcome of this study draws attention to males between the ages of 30 and 60, while adolescent girls and women of child-bearing age (those belonging to the 16-30 age group) are more likely to develop vitamin D deficiency, as they require vitamin D in the form of extra supplements for growth, it said.

Source: Deccan chronicle

Vitamin D Deficiency Linked to Brain Damage, Says Study

A recent study, published by researchers from the University of Kentucky, in the journal Free Radical Biology and Medicine, suggests that low levels of vitamin D may cause brain damage.

Vitamin D is a fat-soluble vitamin present in few natural foods, including fatty fish, cheese and egg yolks; a variety of foods, meanwhile, are artificially fortified with vitamin D, including milk, cereals and margarine. Vitamin D manufacture can also be achieved endogenously, when rays of light strike the skin. This photochemical process triggers the production of vitamin D3 (a.k.a. cholecalciferol) from its precursor, 7-dehydrocholesterol.

Vitamin D confers a number of benefits, ranging from promotion of calcium absorption in the gut, maintaining serum calcium and phosphate levels, as well as bone growth and remodeling. On top of this, vitamin D regulates a number of genes that are involved in cell division, differentiation and an essential form of programmed cellular death (apoptosis). It is thought that vitamin D serves a variety of roles in inflammatory processes and could even serve neuromuscular and immune functions.

The Rat Research Models
The latest scientific research suggests that the vitamin may serve a critical role in protecting the brain from free radical-induced damage. The researchers used a series of rat models to test the influence of differing concentrations of dietary vitamin D. A total of 27 male rats were divided into three separate groups; one group was fed a diet that contained low concentrations of vitamin D (100 IU/kg food), another was used as a control (1000 IU/kg food) and the final group received a diet enriched in the vitamin (10,000 IU/kg food).

The trial began as the rats hit middle-age and lasted for a period of four to five months. The research group measured the level of oxidative and nitrosative stress in a specific part of the rat brains, located in the posterior cortex.

Intriguingly, the group found an elevation in the level of a reactive nitrogen species, called 3-nitrotyrosine, in those rats that had received inadequate levels of vitamin D. Nitrotyrosine is considered a marker of cellular damage and inflammation and has been found to be elevated in a number of pathologies, including inflammatory diseases, lung disease, sepsis and atherosclerosis.

The researchers believe that the increase in nitrotyrosine is caused by disruption of a protein complex (NF-?B) that is recruited during cellular stress. In addition, after performing redox proteomics, a number of proteins in this region of the brain were found to be damaged in those rats that were provisioned low vitamin D diets.

When examining the real-world affect that this vitamin D deficiency had on the rats, the research team established that subjects provided with an abundance of the sunshine vitamin excelled in cognitive performance tests. Specifically, when investigating learning and memory capacity, rats given diets consisting of 100 IU/kg of food were found to lag behind the other two groups, significantly.

The Future
Allan Butterfield was the lead author of the latest study, who works as a professor in the UK Department of Chemistry and as the director of the Center of Membrane Sciences, faculty of Sanders-Brown Center on Aging. Also acting as the director of the Free Radical Biology in Cancer Core of the Markey Cancer Center, Butterfield briefly discussed his research endeavors and what they could mean for elderly populations.

“Given that vitamin D deficiency is especially widespread among the elderly, we investigated how during aging from middle-age to old-age how low vitamin D affected the oxidative the oxidative status of the brain… Adequate vitamin D serum levels are necessary to prevent free radical damage to the brain and subsequent deleterious consequences.”
This problem is exacerbated in developing countries, where food nutrition is problematic. Likewise, individuals that inhabit regions that receive little sunlight and those who work indoors for long periods are also prone to deficiency, as are elderly people who lead sedentary lifestyles.

In the past, prior scientific studies have implicated hypovitaminosis D in Alzheimer’s disease, with a number of researchers suggesting its use as a biomarker of disease progression. A recent study, published in the Journal of Alzheimer’s Disease, entitled Low serum vitamin D concentrations in Alzheimer’s disease: a systematic review and meta-analysis, found there to be low serum vitamin D levels in Alzheimer’s patients, relative to controls.

Meanwhile, a study produced by Lu’o’ng and Nguyen, which explored the beneficial role of vitamin D in Alzheimer’s patients, found that its absence could trigger mood problems and cognitive impairment. They also point to evidence that links vitamin D deficiency to a number of proteins that are adversely affected in Alzheimer’s disease pathology.

Aside from neurological disease, a number of studies have linked deficiency of the vitamin to the development of cancers and cardiovascular pathologies. Osteomalacia and rickets, witnessed in adults and children, respectively, are commonly documented complications of vitamin D deficiency, causing softening and bowing of bones.

In concluding, Butterfield recommends people consult their general practitioners to determine their vitamin D levels, eat food enriched in vitamin D and get a minimum of 10 to 15 minutes of sun exposure every day; he also suggests individuals prone to deficiency should ask their doctor for advice about taking vitamin D supplements.

Source: Guardian express