Premature birth

Premature births may be linked to stress, new Alberta study suggests

A researcher at the University of Lethbridge says the cause of premature births could be linked back to stress in past generations This research could help understand Alberta’s pre-term birth rate, which is the highest in Canada.

Premature births may be linked to stress

Researchers subjected rats to stress late in pregnancy and observed their offspring. They found that the daughters of stressed rats had shorter pregnancies than the daughters of rats not subjected to stress, and that the grand-daughters of stressed rats also showed shorter pregnancies even if their mothers had not been stressed.

“I think if you understand the mechanisms of how this is being generated — the footprint of stress — we have a means of predicting the risk of pre-term birth in future generations and finding certain interventions,” said Gerlinde Metz, a professor of neuroscience and Alberta Heritage Foundation Medical Senior Scholar at the university and one of the researchers on the team.

Metz says stress can alter the genes, meaning mothers-to-be can pass the altered genes on to their babies and that’s why the future generations showed the effects of the original rat’s stress. The study looked at four generations of maternally-related rats.

It found the stressed rats and their offspring also gained less weight during pregnancy and had higher blood glucose levels. As well, their offspring were smaller and had delays in behavioural development, all effects which were amplified over successive generations.

Metz says the study could help provide clues to the causes of pre-term births in humans as well as help other researchers identify the predictors and possible interventions for the pre-term births.

Source; cbc news

Tips for tackling asthma during pregnancy

Expecting a child is the most exciting and happy phase in a woman’s life, but suffering from an asthma attack is the worst nightmare a pregnant lady can face.

As per National Asthma Education Group for the Centers for Disease Control and Prevention (CDC), asthma is one of the most common diseases that can complicate a pregnancy.

It is advisable for pregnant women to identify the early asthma symptoms as the disease’s effects on pregnant women are appalling, Parents India magazine reported.

If asthma becomes uncontrolled, it can bring about a risk for the mother’s as well as for the baby’s health. This situation can even lead to further complications like oxygen deprivation for the baby, morning sickness, vaginal bleeding, high blood pressure and protein in the urine after 20 weeks of pregnancy (preeclampsia), restricted fetal growth, complicated labor, need for a C-section, premature birth, low birth weight and in extreme cases, the baby’s life might be in jeopardy.

Since the fetus gets its oxygen from the mother’s blood, this condition leads to decreased oxygen in the fetal blood.

Swimming is known to be a particularly good exercise for women suffering from asthma. Using an inhaled bronchodilator ten minutes before you exercise may help you better tolerate your recommended exercise during pregnancy.

It is also advisable for the pregnant women who have asthma to get their condition monitored on a regular basis. A check-up once in three weeks is recommended by expert doctors worldwide.

Source: DNA India

Premature Birth Linked to Asthma in Childhood

A new analysis of existing research suggests that premature babies face a higher risk of developing asthma and wheezing disorders when they’re older.

Researchers from Harvard Medical School, the Maastricht University Medical Center in the Netherlands and the University of Edinburgh in Scotland examined 30 studies that included about 1.5 million children.

They found that premature children (born before 37 weeks of gestation) were 46 percent more likely to develop asthma or wheezing problems than kids who weren’t born prematurely. Full-term birth is generally considered about 40 weeks’ gestation.

Very premature children (those born before 32 weeks’ gestation) faced an even higher estimated risk — almost three times that of children born at full term, said Jasper Been, from Maastricht University, and his colleagues.

About 11 percent of children are born prematurely, the study authors said in the report, which was published in the Jan. 28 online edition of the journal PLoS Medicine and these chldren suffer a lot when they go to school. Here are the tips to manage Your Child’s Asthma at School

“The current findings do not support prior suggestions that the association between preterm birth and wheezing disorders becomes less prominent with increasing age,” the researchers wrote in the report. “Instead, the strength of the association was similar across age groups [up to 18 years],” which suggests that the effects of preterm birth on the lungs tend to have life-long consequences.

Although the study found an association between premature birth and respiratory problems such as asthma later in life, it did not prove a cause-and-effect relationship.

Source: web md

Early `water breaking` linked to premature births

A high presence of bacteria at the site where fetal membranes rupture may be the key to understanding why some pregnant women experience their “water breaking” prematurely, researchers at Duke Medicine report.

bacterial presence is associated with thinning of the fetal membranes. More research is needed to understand whether bacterial presence is a cause or consequence of fetal membrane weakening.

“Complications of preterm births can have long-term health effects for both mothers and children,” said study author Amy P. Murtha, M.D., associate professor of obstetrics and gynecology at Duke University School of Medicine. “Our research focuses on why the fetal membranes, or water sac, break early in some women, with the overall goal of better understanding the mechanisms of preterm membrane rupture.”

Composed of two fetal cell layers, the amnion and chorion, fetal membranes play an important role in maintaining pregnancy through gestation. Nearly one-third of all early deliveries are associated with the water breaking in what’s known as preterm premature rupture of membranes, or PPROM.

Previous research from Murtha and her colleagues demonstrated that the chorion has more cell death when infection is present, and that this cell layer may be thinner in women who experience PPROM. Among PPROM patients with infection in the fetal membranes (chorioamnionitis), the cell death within the chorion layer was highest, suggesting that infection may play a role in causing PPROM.

In the current study, the researchers prospectively examined chorion membrane samples to identify a pattern of bacterial presence and association with chorion thinning. They collected membrane samples from a total of 48 women—including PPROM, preterm and term patients—after they gave birth. The researchers measured chorion thinning and bacterial presence in membrane samples collected from both near and far from the rupture site.

In all women, the chorion membrane was thinner at the rupture site than at the distant site. However, chorion thinning was greatest among PPROM patients and was not isolated to the rupture site, as the researchers observed a global chorion thinning even distant from where the membrane ruptured.

The researchers then looked to see if bacteria were present in the membranes and whether bacteria levels correlated with the thinning of the cell layers in the membranes. Interestingly, bacteria were present in all fetal membranes, refuting the traditional understanding that fetal membranes are sterile environments. The amount of bacteria present at the rupture site was higher, which the researchers were not surprised to find.

Among PPROM subjects, bacteria counts were highest compared to all other groups at both the rupture site and distant from the rupture site. Among all subjects, bacterial counts were inversely correlated with chorion thinning: the more bacteria present, the thinner the chorion.

It is unknown if this is a causal relationship, but the link between high bacterial presence at the membrane rupture site provides insight into possible mechanisms behind PPROM.

“We still know little about changes occurring within the fetal membrane in the presence of bacteria, but our data suggest the chorion and its thinning may be the battleground for these changes,” Murtha said.

The researchers are now working to identify the bacteria to determine if specific bacteria are found in PPROM patients. By identifying specific bacteria, the researchers can learn more about the role of bacterial presence, which could eventually lead to preventive treatments.

“For instance, if we think that certain bacteria are associated with premature rupturing of the membranes, we can screen for this bacteria early in pregnancy. We then might be able to treat affected women with antibiotics and reduce their risk for PPROM,” Murtha said. “Our research is several steps away from this, but it gives us opportunities to explore potential targeted therapeutic interventions, which we lack in obstetrics.”

Source: Medical Express