malaria

New device may put DNA testing in doctors’ hands

handheld-genetic-test

It can take days for doctors to determine if a patient infected with malaria carries a drug-resistant version of the disease. The same is true of tuberculosis.

But a new testing device could reduce that time lag to 15 minutes, potentially helping to ensure that patients are correctly treated right away, says the company developing this device.

United Kingdom company QuantuMDX now has a working prototype for a device intended to quickly test a sample of blood, sputum (saliva mixed with mucus) or even tumor cells for genetic markers that provide information to guide a doctor’s decisions on how to treat a patient.

“We want to put a full diagnostic test into the palms of health professionals’ hands,” said Elaine Warburton, chief executive officer of QuantuMDX and the companys cofounder.

The prototype is about the size of an iPad 5, or 6.6 by 9.4 inches (17 by 24 centimeters), but thicker. In about six months, Warburton said she anticipates the device will be reduced to about the size of an iPad mini, 5.3 by 7.9 in. (13 by 200 cm).

The device, currently known as Q-POC (pronounced Q-pock), is still a long way from being used in the clinic. The company still has work to do on the cartridges for use with the handheld prototype, and it needs to run clinical trials testing the device, followed by regulatory approval from bodies such as FDA, Warburton told LiveScience in an email.

Earlier this month at the Consumer Electronics Show in Las Vegas, Jonathan O’Halloran, inventor of the technology and the company’s cofounder, announced plans to launch a crowdfunding campaign. The campaign is expected to begin on Feb. 12 on the site Indigogo.com, to support further development of the Q-POC. The company is also interested in suggestions for a new name and design for the device, Warburton said.

If all goes well, QuantuMDX anticipates commercially launching the device and malaria test cartridge in Africa in 2015, she said.

Source: Fox news

Malaria control efforts saved 3.3 million since 2000, WHO says

Global efforts to curb malaria have saved the lives of 3.3 million people since 2000, cutting global death rates from the mosquito-borne disease by 45 percent and by half in children under 5, the World Health Organization said on Wednesday.

WHO said in its World Malaria Report 2013 that expanded prevention and control measures helped produce declines in malaria deaths and illness. Of the 3.3 million lives saved, most were in the 10 countries with the highest malaria burden and among children under age 5, the group most afflicted by the disease.

“Investments in malaria control, mostly since 2007, have paid off tremendously,” said Ray Chambers, the United Nations secretary-general’s special envoy for malaria.

According to the WHO report, child deaths fell to fewer than 500,000 in 2012.

Overall, there were an estimated 207 million cases of malaria in 2012, which caused some 627,000 deaths, according to the report, which includes information from 102 countries with malaria transmission.

The estimated number of malaria cases per 1,000 at-risk individuals – a figure that takes population growth into account – shows a 29 percent drop globally between 2000 and 2012, and a 31 percent drop in Africa.

During the same period, death rates per 1,000 at-risk individuals fell by 45 percent globally and 51 percent in children under age 5.

“This remarkable progress is no cause for complacency: absolute numbers of malaria cases and deaths are not going down as fast as they could,” WHO Director-General Dr Margaret Chan said in a statement accompanying the release of the report.

“The fact that so many people are infected and dying from mosquito bites is one of the greatest tragedies of the 21st century.”

FUNDING CUTS

Malaria is endemic in more than 100 countries worldwide but can be prevented by the use of bed nets and indoor spraying to keep the mosquitoes that carry the disease at bay. The mosquito-borne parasitic disease kills hundreds of thousands of people a year, mainly babies in the poorest parts of sub-Saharan Africa.

An estimated 3.4 billion people continue to be at risk for malaria, mostly in Southeast Asia and in Africa where around 80 percent of cases occur.

Chambers said progress against malaria has been threatened by funding cuts in 2011-2012, which translated into a flattening in the curve of the decline. The WHO noted significant drops in delivery of insecticide-treated bed nets in its 2013 report.

But that could begin to ease. Last month, the Global Fund to Fight AIDS, Tuberculosis and Malaria, UNICEF, the UK’s Department for International Development and the U.S. President’s Malaria Initiative agreed to provide over 200 million nets in the next 12 to 18 months, which will replace 120 million existing bed nets and provide 80 million new ones.

WHO also continues to track emerging parasite resistance to artemisinin, the core component of malaria drugs known as artemisinin-based combination therapies, or ACTs, and mosquito resistance to insecticides.

Four countries in Southeast Asia reported artemisinin resistance in 2013, and 64 countries found evidence of insecticide resistance, suggesting recent gains against malaria are still “fragile,” Dr Robert Newman, director of the WHO Global Malaria Programme, said in a telephone interview.

“The greatest threat to the future isn’t biological, but financial. It’s not having enough money to stay a step ahead,” Newman said.

Source: reuters

New drug target to help fight malaria identified

A team of researchers has identified a key metabolic enzyme that is required by the common malaria parasites at all stages of its life cycle for survival in humans.

Co-first author Marcus C. S. Lee, PhD, associate research scientist in microbiology and immunology at Columbia University Medical Center (CUMC) said the study is important because most anti malarials are effective at killing the parasites only as they circulate in the bloodstream. However, the parasites can hide in the liver for years before reemerging and triggering a relapse of the disease.

The other co-first author is Case W. McNamara, PhD, research investigator at the Genomics Institute for the Novartis Research Foundation. The study leaders are Elizabeth A. Winzeler, PhD, professor of pharmacology and drug discovery at University of California San Diego, and Thierry Diagana, head of Novartis Institute for Tropical Diseases in Singapore.

The enzyme, phosphatidylinositol 4-kinase (PI4K), was found by screening more than a million drug compounds against Plasmodium falciparum, the parasite responsible for the most lethal form of malaria. Using this screen, the researchers found a class of compounds known as imidazopyrazines, which are capable of killing several species of Plasmodium at each stage of the parasites’ life cycle in its vertebrate host.

The researchers identified the target of the imidazopyrazines by evolving parasite cell lines that were resistant against the drugs and then analyzing the parasites’ genomes for the changes responsible for conferring resistance. Those genetic changes pointed to the gene that encodes PI4K.

The CUMC team, led by David Fidock, PhD, professor of microbiology and immunology and medical sciences (in medicine), used novel genetic tools to confirm that PI4K was being directly targeted by the imidazopyrazines.

Then, using cellular imaging, it was found that imidazopyrazines interfere with the function of PI4K on the parasite Golgi (the organelle that packages proteins for delivery to other cellular destinations). ”

The study is published in the journal Nature.

Source: top news

Malaria, jaundice claim 20 lives in Arunachal in a week

Diseases like malaria and jaundice have claimed 20 lives since last week in Longding district of Arunachal Pradesh, an official report said today.

“This is not the first time when such an epidemic has broken out in Wancho area. In the past, too many such epidemics have been reported.

The reason may be due to the unhygienic way of living and lack of proper health-care facilities,” the report said.

“Though medicines have been rushed they are hardly adequate,” it said. When contacted, Parliamentary Secretary for Information and Public Relation Department, Thangwang Wangham, said that the situation is alarming as every day new cases are being reported.

Wangham, who is the local MLA, said though health workers were in the field there was no tangible respite. The MLA, who is camping at Longding to monitor the situation, has appealed the state government to send relief and more medicines.
Source: one India News

Malaria ‘linked’ to household size

Researchers have found that malaria eradication is related more to household size than to a country’s wealth or temperature.

University of Guelph’s economics professor Ross McKitrick and two Finnish professors, Larry and Lena Hulden, found that when average household size drops below four persons, malaria extermination is much more likely.

Malaria is transmitted by infected mosquitoes. The research team examined data on malaria insect vectors, as well as demographic, sociological and environmental factors for 232 countries. Malaria is still prevalent in 106 countries.

McKitrick said that Malaria-bearing mosquitoes mainly feed at night, and tend to return to the same location for blood meals, asserting that the more people who sleep in one area, the greater the likelihood of an infected mosquito spreading the parasite to a new, uninfected victim.

The researchers looked at factors such as gross domestic product per capita, urbanization and slums, latitude, mean temperature, forest coverage, national DDT use, household size and even religion.

The study has been published in the Journal of the Royal Statistical Society Series A.

Source: Deccan Chronicle