living well

Meditation can change gene expression

Scientists have found the first evidence that mindfulness meditation can reduce levels of pro-inflammatory genes which can lead to faster physical recovery from a stressful situation.

The new study by researchers in Wisconsin, Spain, and France found specific molecular changes in the body following a period of mindfulness meditation.

The study investigated the effects of a day of intensive mindfulness practice in a group of experienced meditators, compared to a group of untrained control subjects who engaged in quiet non-meditative activities.

After eight hours of mindfulness practice, the meditators showed a range of genetic and molecular differences, including altered levels of gene-regulating machinery and reduced levels of pro-inflammatory genes, which in turn correlated with faster physical recovery from a stressful situation.

“To the best of our knowledge, this is the first paper that shows rapid alterations in gene expression within subjects associated with mindfulness meditation practice,” said study author Richard J Davidson, founder of the Center for Investigating Healthy Minds and the William James and Vilas Professor of Psychology and Psychiatry at the University of Wisconsin-Madison.

“Most interestingly, the changes were observed in genes that are the current targets of anti-inflammatory and analgesic drugs,” said Perla Kaliman, first author of the article and a researcher at the Institute of Biomedical Research of Barcelona, Spain, where the molecular analyses were conducted.

Mindfulness-based trainings have shown beneficial effects on inflammatory disorders in prior clinical studies and are endorsed by the American Heart Association as a preventative intervention. The new results provide a possible biological mechanism for therapeutic effects.

The results show a down-regulation of genes that have been implicated in inflammation. The affected genes include the pro-inflammatory genes RIPK2 and COX2 as well as several histone deacetylase (HDAC) genes, which regulate the activity of other genes epigenetically by removing a type of chemical tag.

The extent to which some of those genes were downregulated was associated with faster cortisol recovery to a social stress test involving an impromptu speech and tasks requiring mental calculations performed in front of an audience and video camera.

There was no difference in the tested genes between the two groups of people at the start of the study. The observed effects were seen only in the meditators following mindfulness practice, researchers said.

In addition, several other DNA-modifying genes showed no differences between groups, suggesting that the mindfulness practice specifically affected certain regulatory pathways.

The study was published in the journal Psychoneuroendocrinology.

Source: business standard

 

It is possible to think yourself well

What if you had the ability to heal your body just by changing how you think and feel? I know it sounds radical, coming from a doctor. When people are doing everything “right”—eating veggies, avoiding red meat and processed foods, exercising, sleeping well and so forth—we should expect them to live long, prosperous lives and die of old age while peacefully slumbering, right? So why is it that so many health nuts are sicker than other people who pig out, guzzle beer and park in front of the TV?

I consider myself one of those health nuts. I drink my green juice, take my vitamins, hike and practice yoga daily, get quality sleep, see a doctor and avoid harmful toxins. And yet I have come to believe that the purely physical realm of illness—the part you can diagnose with laboratory tests—is only part of the equation. It’s a big part, mind you, but not the whole shebang. My experience with patients (as well as my personal background) has led me to the conclusion that whether they become sick or stay healthy, as well as whether they remain ill or manage to heal themselves, might have more to do with everything else that’s going on in their lives than with any specific health standard they abide by.

When healthy habits aren’t enough
Five years ago, I started working in an integrative medicine practice. My new patients were some of the most health-conscious people I’ve ever had the privilege to serve. Many of them ate a vegan diet, worked out, slept soundly each night and took vitamins every morning. But some of them were also mysteriously sick, complaining of fatigue, aches, gastrointestinal disturbances and other symptoms. I was baffled! I ran batteries of tests, and occasionally I would pick up something that eventually resulted in the complete resolution of a patient’s symptoms. But more often than not, I would find nothing.

I was really motivated to solve the puzzle of why these “healthy” patients were so sick. Instead of focusing exclusively on physician-recommended behaviors, medical history and other traditional factors, I dug deep into their personal lives. I asked them questions: “What do you love about yourself? What’s missing from your life? What do you appreciate about your life? Are you in a romantic relationship? If so, are you happy? If not, do you wish you were? Are you fulfilled at work? Do you feel like you’re in touch with your life’s purpose? Do you feel sexually satisfied? Do you express yourself creatively? Do you feel financially stable, or are you stressed about money? If your fairy godmother could change one thing about your life, what would you wish for?”

My patients’ answers often gave me more insight into why they might be sick than any lab test or exam could. They were unhealthy not because of bad genes or poor habits or rotten luck, but because they were lonely or miserable in their relationships, stressed about work, freaked out about their finances or profoundly depressed.

On the flip side, I had other patients who ate junk, forgot to take their supplements, rarely exercised and enjoyed seemingly perfect health. Their responses revealed that their lives were filled with love, fun, meaningful work, creative expression, spiritual connection and other traits that differentiated them from the sick health enthusiasts.

Source: health