Diabetes

Exercise helps prevent diseases in kids

New studies have shown that when children increase their level of physical activity, they experience positive health benefits, which include less body fat, increased muscular strength and reduced risk factors for major diseases like diabetes, cardiovascular disease and other metabolic and lifestyle-related disorders, quickly.

The studies were conducted in a lab led by David Nieman,Dr.P.H., FACSM, a professor of health and exercise science in Appalachian’s College of Health Sciences.

In the study, 200 obese Chinese children were split into two groups. One group took part in a summer camp where they exercised three hours in the morning and three hours in the afternoon doing a number of activities that included swimming, running, cycling and ping pong.

The second group continued with their normal lives. Both groups maintained a caloric intake of 1,600 to 2,000 calories a day. The average child in the summer camp lost six to eight kilograms or 13 to 17 pounds.

“All of that exercise and weight loss combined to bring most of their risk factors down,” Nieman said. “Their blood pressure went down and insulin sensitivity improved. They were able to handle their glucose better. They had a reduction in total cholesterol. So the overall metabolic health of these children improved in just six weeks.”

In another study conducted as part of the BioMoto STEM Initiative, Nieman’s laboratory tested seventh and eighth graders from the greater Charlotte area using a sophisticated battery of physical fitness tests. They found a key concern for these youth is their body fat levels.

The study is published in journal of Sport and Health Science.

Source: deccan chronicle

 

Diabetes linked to higher liver cancer risk

A new study has found that diabetes was associated with an increased risk for developing a type of liver cancer called hepatocellular carcinoma.

‘People with diabetes have a two- to threefold higher risk for hepatocellular carcinoma compared with those without diabetes,’ V. Wendy Setiawan, Ph.D., assistant professor in the Department of Preventive Medicine at Keck School of Medicine of the University of Southern California, said.

‘We also found that the interethnic differences in the prevalence of diabetes were consistent with the pattern of hepatocellular carcinoma incidence observed across ethnicities: Ethnic groups with a high prevalence of diabetes also have high hepatocellular carcinoma rates, and those with a lower prevalence of diabetes have lower hepatocellular carcinoma rates,’ Setiawan said. (Read: ‘Anyone who is above the age of 35 is at risk of diabetes’)

Setiawan and colleagues examined if the association between diabetes and hepatocellular carcinoma differed by race or ethnic group. They analyzed data from more than 150,000 people enrolled in the Multiethnic Cohort Study between 1993 and 1996.

Compared with non-Hispanic whites, Latinos had 2.77 times the risk for being diagnosed with hepatocellular carcinoma, the highest risk identified. Native Hawaiians had 2.48 times the risk; African-Americans, 2.16; and Japanese-Americans, 2.07.

The prevalence of diabetes was consistent with that of hepatocellular carcinoma. Sixteen percent of Hawaiians, 15 percent of Latinos and African-Americans, 10 percent of Japanese-Americans, and 6 percent of non-Hispanic whites had diabetes.

The study was presented at the Sixth AACR Conference.

Source: health India

Sleep disturbances linked to poor quality of life in obese

A new research has showed that poor sleep quality is strongly associated with mood disturbance and lower quality of life among people with extreme obesity.

Results show that 74.8 percent of participants were poor sleepers, and their mean self-reported sleep duration was only six hours and 20 minutes.

Fifty-two percent of study subjects were anxious, and 43 percent were depressed. After controlling for age, sex, hypertension, diabetes, and obstructive sleep apnea, sleep quality and daytime sleepiness were significantly associated with mood disturbance and quality of life impairment.

“There was a clear association between the sleep problems such as short sleep duration and the psychological disorders and with quality of life,” Dr. G. Neil Thomas, from the University of Birmingham in the United Kingdom, said. “These associations remained significant even after adjusting for a range of potential confounders.

According to the authors, the potential role of sleep in the health and well-being of individuals with severe obesity is underappreciated. The results suggested that the early detection of disturbed sleep could prevent the potential development and perpetuation of psychological problems among people with extreme obesity.

The study was published in the journal Sleep.
Source: dna India

New data backs promise of long-acting Sanofi insulin

An improved version of Sanofi’s diabetes drug Lantus is better than the old one at controlling blood sugar levels and comes with fewer hypoglycemic events, new late-stage trial data showed on Tuesday.

The treatment is one of several drugs Sanofi is betting on to defend its No.2 spot on the world’s $42 billion diabetes market as its superstar product Lantus, the world’s most prescribed insulin, will lose patent protection by 2015.

The long-acting insulin, known as U300, requires less frequent or lower dosing than Lantus and offers a more consistent insulin release. It is similar to Novo Nordisk’s Tresiba (degludec), also in development.

Analysts expect Sanofi to seek regulatory approval for U300 in the United States and Europe next year and for the drug to reach global sales of $872 million by 2017, according to forecasts compiled by Thomson Reuters Cortellis.

The detailed Phase III results unveiled at the World Diabetes Congress in Melbourne showed U300 was better than Lantus at controlling blood sugar lows at night, a common side effect in diabetics treated with insulin.

The drug also lowered the incidence of hypoglycemic events at any time of the day across the six-month study period.

U300 met its goal in three other Phase III clinical trials, showing similar blood sugar level control as Lantus in patients with type 2 diabetes not previously treated with insulin and uncontrolled on oral medication, as well as in patients with type 1 diabetes already treated with insulin.

Lantus, also known as insulin glargine, was developed in the 1990s and is currently Sanofi’s top-selling drug. It reaped around 5 billion euros ($6.78 billion) in revenue last year.

Sanofi needs a successor for the drug and is also developing a pen-shaped device, known as LixiLan, that combines Lantus with Lyxumia, another diabetes treatment belonging to a class of drugs known as GLP-1 analogues.

The successful launch of both U300 and LixiLan could strengthen Sanofi against rival drugs such as Novo Nordisk’s Tresiba (degludec) and IDegLira, a combination of Tresiba and Victoza.

Novo Nordisk, the global leader in diabetes, faced a setback earlier this year when the U.S. Food and Drug Administration asked for further clinical studies for Tresiba, delaying its potential launch on the world’s largest pharmaceutical market until 2017 at the earliest.

Source: Reuters

Skipping meals can lead to weight gain, diabetes

Are you skipping your meals as part of a quick fix diet plan to lose weight? You are in for trouble. Because skipping meals does more bad than good to your body. Not only is your body deprived of essential nutrients but this also drastically affects the metabolism leading to weight gain and diabetes.

Most people tend to skip breakfast for instant weight loss. But in their desperate attempt they send their metabolism for a toss. Metabolism is the simple process of breaking your food into smaller, usable parts that helps you stay active through the day.  When you skip meals your metabolism has nothing to do. As a result your metabolism is unable to break down portions that you eat later in the day, and the food gets stored as fat leading to weight gain.

Skipping meals also drastically affects blood sugar levels. During metabolism some part of this food that you eat is stored as fat, while other parts enter the bloodstream as sugar, to provide you with energy throughout the day. Not eating at regular intervals can drastically lower your blood sugar levels making you susceptible to developing diabetes later in life.

So eat at the right times, eat healthy and exercise to stay fit.

Source: Zee news

Sugary drinks may up uterine cancer risk

Postmenopausal women who consume sugar-sweetened drinks are at a higher risk of developing cancer of the endometrium – the lining of the uterus – a new study has warned.

Researchers found that postmenopausal women who reported the highest intake of sugar-sweetened beverages had a 78 per cent increased risk for estrogen-dependent type I endometrial cancer (the most common type of this disease).

This association was found in a dose-dependent manner: the more sugar-sweetened beverages a woman drank, the higher her risk.

“Although ours is the first study to show this relationship, it is not surprising to see that women who drank more sugar-sweetened beverages had a higher risk of estrogen-dependent type I endometrial cancer but not estrogen-independent type II endometrial cancer,” said researcher Maki Inoue-Choi.

“Other studies have shown increasing consumption of sugar-sweetened beverages has parallelled the increase in obesity,” said Inoue-Choi, who led the study as a research associate in the Division of Epidemiology and Community Health of the University of Minnesota School of Public Health.

“Obese women tend to have higher levels of estrogens and insulin than women of normal weight. Increased levels of estrogens and insulin are established risk factors for endometrial cancer,” said Inoue-Choi.

Inoue-Choi and colleagues used data from 23,039 postmenopausal women who reported dietary intake, demographic information, and medical history in 1986, prior to the cancer diagnosis, as part of the Iowa Women’s Health Study.

Dietary intake was assessed using the Harvard Food Frequency Questionnaire (FFQ), which asked study participants to report intake frequency of 127 food items in the previous 12 months.

Between 1986 and 2010, 506 type I and 89 type II endometrial cancers were recorded among the women Inoue-Choi and colleagues studied.

They did not find any association between type I or type II endometrial cancers and consumption of sugar-free soft drinks, sweets/baked goods, and starch.

Source: Indian Express

 

Exercise can help kids stave off negative effects of maternal obesity

Researchers have found that off springs whose mothers were fed a high-fat diet during pregnancy and nursing were able to stave off some of the detrimental health effects of obesity by exercising during their adolescence.

It was found that even though the rat offspring weighed the same as their sedentary counterparts, the exercising rats had fewer fat deposits and their brains were better able to respond to a hormone known to suppress the appetite, long after they stopped running on their exercise wheels.

Because mammals (including rats and humans) share much of their biology, the findings suggest that childhood exercise might help mitigate some of the risks that human children of obese parents are biologically primed to follow in their parents’ footsteps and to develop diabetes and other obesity-related disorders.

“Just three weeks of exercise early in life had a persistent effect on the satiety centres of the brains of these rat pups,” study’s lead author Kellie L. K. Tamashiro, Ph.D., an associate professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine, said. “If we can find a way to take advantage of th

at phenomenon in humans that would be great, because preventing obesity is probably going to be much easier to do than reversing it.”

Tamashiro and her colleagues fed pregnant rats a high-fat diet and continued that diet while they were nursing their pups. The animals were weaned on a healthier, standard low-fat diet and at four weeks of age, the equivalent of rodent early adolescence, some were given free access to running wheels in their cages, while the others remained sedentary.

To determine the impact of the exercise on appetite, at 14 weeks of age, the rats’ brains were injected with the appetite-suppressing hormone leptin. Those that had exercised weeks before ate less, while the sedentary rats showed no differences in their appetites.

The study is published in the American Journal of Physiology

Go nuts! Healthy facts about nuts!

Good things come in small packages and nuts are no exceptions. These nuggets are packed with healthy fats, protein, vitamins, and minerals. Studies have suggested that people who include nuts, including peanuts, in their diet have fewer common health problems such as heart disease, cancer, diabetes, etc. Here are some facts you should know before including nuts in your diet:

Nut varieties

A nut usually have a hard shell and a seed and most fruits we called nuts are not technically nuts nonetheless they provide similar health benefits. They include hazelnuts, chestnuts, and acorns, almonds, Brazil nut, candlenut, cashew, Chilean hazelnut or Gevuina, macadamia,   Malabar chestnut, pecan, mongongo, peanut, pine nut, pistachio and walnut.

How much to eat

According to the American Heart Association, include 4 servings of nuts a week in your diet. A serving is a small handful or 1.5 ounces of whole nuts or 2 tablespoons of nut butter. Avoid salted or oiled ones; instead, eat them raw or dry roasted

Calorie count

Almonds, cashews and pistachios have the lowest calorie count at 160 per ounce while macadamia nuts and pecans have the highest at 200 per ounce.

How to eat

You can have them as snacks whenever you feel hungry or sprinkle them over desserts and salads

Source: Zee News

‘Painful’ pinpricks may soon be history for diabetics

A new nanotechnology-based technique for regulating blood sugar in diabetics may give patients the ability to release insulin painlessly using a small ultrasound device, allowing them to go days between injections – rather than using needles to give themselves multiple insulin injections each day.

The technique involves injecting biocompatible and biodegradable nano particles into a patient’s skin. The nanoparticles are made out of poly(lactic-co-glycolic) acid (PLGA) and are filled with insulin.

Each of the PLGA nanoparticles is given either a positively charged coating made of chitosan (a biocompatible material normally found in shrimp shells), or a negatively charged coating made of alginate (a biocompatible material normally found in seaweed).

When the solution of coated nanoparticles is mixed together, the positively and negatively charged coatings are attracted to each other by electrostatic force to form a “nano-network.”

Once injected into the subcutaneous layer of the skin, that nano-network holds the nanoparticles together and prevents them from dispersing throughout the body.

The coated PLGA nanoparticles are also porous. Once in the body, the insulin begins to diffuse from the nanoparticles. But the bulk of the insulin doesn’t stray far – it is suspended in a de facto reservoir in the subcutaneous layer of the skin by the electrostatic force of the nano-network. This essentially creates a dose of insulin that is simply waiting to be delivered into the bloodstream.

Using the new technology developed by Dr. Zhen Gu, senior author of a paper on the research and an assistant professor in the joint biomedical engineering program at NC State and UNC-Chapel Hill, and his team, a diabetes patient doesn’t have to inject a dose of insulin – it’s already there. Instead, patients can use a small, hand-held device to apply focused ultrasound waves to the site of the nano-network, painlessly releasing the insulin from its de facto reservoir into the bloodstream.

The study has been published online in Advanced Healthcare Materials.

Source: Yahoo News

One in 10 adults suffers from hypothyroidism, finds survey

HypothyroidOne in 10 adults suffers from hypothyroidism, with the prevalence of the condition higher in inland cities than in coastal locations, says a countrywide study.

The seafood diet of coastal people may help prevent the disease, said experts in reaction to the findings.

The study, published in the Indian Journal of Endocrinology and Metabolism, shows that out of the 5,376 people who were surveyed, 10.95% were found to be suffering from hypothyroidism.

Hypothyroidism is a condition characterized by abnormally low thyroid hormone production, which affects the entire body system along with a person’s lifestyle.

“Of the 1,259 people studied in Mumbai, 9.61 per cent were diagnosed with hypothyroidism,” Dr Mahesh Padsalge, the city investigator of the study, said. “Out of these, 2.86 per cent did not even know that they were suffering from it.”

The study found that inland cities such as Bangalore, Delhi, Kolkata, Ahmedabad and Hyderabad had a higher prevalence of hypothyroidism compared to coastal locations such as the city, Goa and Chennai.

“It is just a theory and not a proven fact, but we believe that people in coastal areas have a lower risk of hypothyroidism because of iodine-rich diet,” Dr A G Unnikrishnan, principal investigator of the study, said. “Iodine is found in the head portion of fish and is an element required in the production of thyroid hormone.”

If left untreated, hypothyroidism can cause elevated cholesterol levels, an increase in blood pressure, an increased rate of cardiovascular complications, decreased fertility, and depression. In pregnant women, it can cause placental abnormalities and put the baby’s health at increased risk.

These symptoms are often confused with other disorders, making thyroid disorders one of the most under-diagnosed in the country.

The study revealed that women were three times more likely to be affected than men; of the affected population, 15.86 per cent were women and 5.02 per cent men. The finding was especially true for those in midlife, that is the age bracket of 46-54 years.

Researchers are still trying to figure out why women are more prone to the disorder.

“Thyroid disorders in India are characterized by a high prevalence, minimal diagnosis, poor awareness and low involvement of doctors in treatment,” Unnikrishnan said. “There is a growing urgency to create awareness of thyroid disorders, the need for early and regular diagnosis and the importance of following a recommended treatment regime.”

Like diabetes, there is no permanent cure for most forms of thyroid disorders, but with medication and precise treatment, these can be controlled so that patients lead normal lives.

Source: Press display