Malaria: High risk focused in 10 African countries

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Gains in fighting malaria in sub-Saharan Africa have left the highest risk for the disease concentrated in 10 countries, according to a study published by The Lancet medical journal.

Nigeria, Democratic Republic of Congo, Uganda, Ivory Coast, Mozambique, Burkina Faso, Ghana, Mali, Guinea and Togo together account for 87 percent of areas that have the highest prevalence of malaria, it said.

The study assessed the effectiveness of the battle against malaria, which went into higher gear with the launch of the Roll Back Malaria initiative in 2000.

Since then, financial support has risen from $100 million (73 million euros) annually to about $2 billion (1.46 billion euros).

The researchers drew up a map of the changing face of malaria from thousands of surveys of prevalence of the disease among children in 44 countries.

They set down three categories of risk: high, meaning places where more than 50 percent of the population were likely to be infected by the Plasmodium falciparum parasite; moderate (10 to 50 percent of the population infected); and low (less than 10 percent).

From 2000 to 2010, the number of people living in areas of high-risk infection fell from 219 million to 184 million, a decline of 16 percent.

But the numbers living in moderate-risk locations rose from 179 million to 280 million, a rise of 57 percent.

The good news was that the tally of people living in low-risk areas rose from 131 million to 219 million.

Four countries — Cape Verde, Eritrea, South Africa and Ethiopia — joined Swaziland, Djibouti and Mayotte in the elite club of countries where transmission levels are so low that elimination of malaria is a realistic goal.

The researchers said the overall picture was mixed, and important gains had been partly offset by population increase — over the decade, an extra 200 million people were born in places with malaria.

“Substantial reductions in malaria transmission have been achieved in endemic countries in Africa over the period 2000-2010,” the paper said.

“However, 57 percent of the population in 2010 continued to live in areas where transmission remains moderate to intense and global support to sustain and accelerate the reduction of transmission must remain a priority.”

In its 2013 report on malaria, the World Health Organisation (WHO) last December said 3.3 million lives had been saved worldwide since 2000.

Even so, the mosquito-borne disease still killed 627,000 people last year, mainly children in Africa and Southeast Asia.

The agency pointed to a shortage of funding and a lack of access to artemisinin malarial medicines and basic remedies such as bednets remained a serious problem, it said.

Source: New vision


Sitting linked to increased risk for disability, study shows

Here’s another reason desk jockeys need to get up and move. Researchers are finding that sedentary behaviors like sitting even just an hour extra per day can up your risk for disabilities in later life — even if you are a moderately active gym rat.

The study published Wednesday in the Journal of Physical Activity and Health is the first to show that sedentary behavior alone may be an independent risk factor for disability, separate from lack of moderate physical activity, its authors say.

To be clear, exercise is important, but it is only the beginning of a healthy lifestyle, said lead author Dorothy Dunlop, Ph.D., professor of medicine at Northwestern University Feinberg School of Medicine in Chicago.

“The message is that we can work on what the government recommends in terms of moderate physical activity, but we need to reduce sitting time by replacing it with some light activity,” Dunlop said. That doesn’t mean sweat and spandex, but rather simple activities like pushing a grocery cart, strolling through a museum, and even getting up once an hour to walk around.

The researchers strapped devices to the waists of some 2,200 adults aged 60 and older to monitor their activity and found that every additional hour a day spent sitting was strongly linked to a doubling of the risk of disability. So, if one 60-something year old person is sedentary for 12 hours a day, and another is sedentary for 13 hours a day, the second individual is 50 percent more likely to be disabled, according to the study.

“I’m not surprised that 30 minutes of activity several times a week doesn’t compensate for nine hours a day sitting around,” said family medicine specialist Dr. Robert Truax of University Hospitals Case Medical Center in Cleveland. The good news, he said, is that it’s never too late to get up off our butts and get healthier.

Source: NBC news


FDA approves Chelsea Therapeutics drug for low blood pressure

Chelsea Therapeutics International Ltd’s drug Northera, which treats a rare form of low blood pressure associated with neurological disorders such as Parkinson’s disease, has won U.S. approval, the Food and Drug Administration said on Tuesday.

The company’s shares rose 34 percent to $6.63 in after-market trading.

The drug’s label will carry a boxed warning, the most serious possible, of the risk of supine hypertension, or increased blood pressure while lying down, a danger that can cause stroke.

In January, an advisory panel to the FDA recommended approval but also suggested the company conduct a follow-up study to prove durable benefit. Panelists said gaps in clinical data made it hard to determine whether Northera, which appears effective after a week’s treatment, is effective over the long term.

The FDA followed the recommendation and approved the drug on an “accelerated” basis. This allows for approval a drug to treat a serious disease based on an intermediate measure while the company conducts more trials.

In the meantime, the FDA said, “it is essential that patients be reminded that they must sleep with their head and upper body elevated. Supine blood pressure should be monitored prior to and during treatment and more frequently when increasing doses.”

Chelsea first filed for approval of Northera in 2011. The FDA rejected the drug in 2012 and asked for additional data. The company is also testing the drug, known generically as droxidopa, in mid-stage studies to treat fibromyalgia and intradialytic hypotension.

Source: yahoo news

 


Lilly lung cancer drug improves survival in late-stage trial

An experimental cancer drug developed by Eli Lilly and Co, touted by some to be the company’s next blockbuster, significantly improved survival rates in lung cancer patients, sending the company’s shares up 3 percent in early trading.

Lilly needs new drugs to offset declining sales of its older drugs as they lose patent protection.

Ramucirumab, designed to treat multiple cancers, has the potential to generate annual sales of $1.5 billion by 2020, according to some analysts.

The drug has already been shown be successful in treating stomach cancer, and Lilly is waiting for approval from the U.S. Food and Drug Administration to market it for that disease.

The latest results could help allay some concerns about the drug after it failed to delay the progression of breast cancer in a late-stage trial last year.

The late-stage lung cancer trial compared a combination of ramucirumab and a common chemotherapy drug, docetaxel, with a combination of a placebo and docetaxel in treating patients with non-small cell lung cancer.

The trial, known as Revel, showed that ramucirumab significantly improved overall survival rates as well as improving survival rates without the cancer worsening.

Lilly did not provide details of the trial results, which it said would be presented at a scientific meeting.

The company said on Wednesday that it planned to submit the first application for marketing approval later this year.

Data from two other studies to test the drug’s effectiveness to treat liver and colorectal cancer are expected later this year, Lilly said.

BMO Capital Markets analyst Alex Arfaei expressed caution about the latest results.

“We believe Revel needs to show at least (a) 2-3 month improvement in overall survival to be considered clinically meaningful,” he said in a note.

Ramucirumab, which Lilly acquired through its $6.5 billion purchase of ImClone Systems Inc in 2008, works by blocking development of blood vessels that feed tumors – a process known as angiogenesis.

Source: Fox news


Fecal Transplant Regulations Are Too Strict, Researchers Say

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Physicians use fecal transplants to treat certain intestinal infections, but the procedures recently came under strict regulations, with the Food and Drug Administration managing the transplants as though they were a drug treatment.

This regulation has made it harder for patients to receive fecal transplants, and in a new paper, some researchers are calling for the transplants to instead be regulated as a tissue, akin to blood donations.

The raw material for fecal transplants isn’t hard to come by, and so in the face of what some see as current over-regulation, an underground market for the transplants will likely spring up, the researchers argued today in the journal Nature.

At the same time, they said, more research is needed on the long-term effects of fecal transplants.

Regulating fecal transplants as a tissue may allow for better research on their possible uses in treatments, while protecting patients from harm, the researchers, from MIT and Brown University, wrote.

“I think regulating it as a tissue product would both provide access as needed and the research that could bring some pretty exciting new treatments on the scene,” said Mark B. Smith, an author of the article and a doctoral candidate at MIT.

Fecal transplants have been tested since the 1950s, and last year the first randomized controlled trial showed a strong benefit in helping patients with recurrent C. difficile, a bacterial infection that causes painful diarrhea, often following the use of antibiotics, and kills 14,000 people yearly in the United States.

But following the treatment’s success, some doctors began offering fecal transplants for other conditions as well — including those for which any potential benefit remains unproven. The FDA took action in 2013, regulating the treatment, but also granting an exemption for its continued use in patients who had C. difficile infections. This use would not require special permissions.

However, the result may be a case of both under- and over-regulation, today’s editorial argues. While medical societies have issued guidelines for using the treatment, there are no hard and fast rules for screening fecal matter, as there are with blood donations.

Source: Huffington Post


Student realizes he has cancer, thanks to Reddit post

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Taylor Tyree was just browsing the social media site Reddit when he came upon another user’s (rather graphic) picture of his testicle, which had just been removed due to cancer.

Tyree, 21, perused the comments associated with the picture and saw the original poster, a Redditor by the name of “uniballer,” described the symptoms he had ahead of being diagnosed with testicular cancer. Tyree realized he had the same symptoms.

“I went to the comments and was reading through and he was talking about symptoms and what not … it was like, wait, I have something similar to this,”

Tyree, a student at Colorado School of Mines, went to the student health center for an exam. He got an ultrasound, CAT scan and X-ray, and was told he had a large cancerous mass in his left testicle.

“It was about four months after I first started noticing the symptoms, so I’m really lucky that it actually didn’t spread to anywhere else,” Tyree said.

Tyree says Reddit “saved his life” because it prompted him to go to a doctor, rather than waiting for months before getting checked out. He even communicated with “uniballer” throughout his diagnosis and his surgery to have his testicle removed.

“He’s a really nice guy, he’s been very helpful,” Tyree said. “He said I should talk to other people going through this, it will help with recovery, and I agree.”

Tyree had surgery on Friday but is looking forward to getting back to school. His Reddit post has garnered more than 1,000 comments, and Tyree hopes he can help others in similar situations.

“I still have, like, a few hundred comments to go through, but I’ll try to answer as many questions as I can and if anyone has any questions, they can message me and I can try to help them as well,” Tyree said.

Source: Fox news


Can Pizza Prevent Norovirus?

You may have heard of binging on pizza as a cause of stomach distress, but how about a a cure?

Researchers found that a chemical in oregano called carvacrol causes norovirus to break down in mice, according to a study published today in the Journal of Applied Microbiology.

“Carvacrol could potentially be used as a food sanitizer and possibly as a surface sanitizer, particularly in conjunction with other antimicrobials,” Dr. Kelly Bright, who led the research at the University of Arizona said in a press release. “We have some work to do to assess its potential but carvacrol has a unique way of attacking the virus, which makes it an interesting prospect.”

Carvacrol, which gives oregano its distinctive flavor, caused the layer of proteins surrounding the vomit-inducing virus to break down. Another antimicrobial would then be able to get into the virus and kill it.

Since carvacrol doesn’t produce any noxious fumes or by-products, it has good potential to be used in sanitizers for schools or hospitals, the researchers noted.

Oregano has developed a reputation as a super-spice. In 2012, researchers from Long Island University discovered that it may also be used to treat prostate cancer. In that study, researchers found that carvacrol could be used to induce “cell suicide.”

“Some researchers have previously shown that eating pizza may cut down cancer risk,” Dr. Supriya Bavadekar, assistant professor of pharmacology at Long Island University said in a press release. “This effect has been mostly attributed to lycopene, a substance found in tomato sauce, but we now feel that even the oregano seasoning may play a role.”


WHO’s Anti-Smoking Guidelines Save 13 Million In China

Anti-smoking campaigns have proven effective in some parts of the United States, but what effect could they have on a country ranked third among the number of active smokers? Guidelines implemented by the World Health Organization (WHO) could prevent up to 13 million smoking-related deaths in China by 2050 and could reduce the number of smokers by more than 40 percent.

According to the WHO, half of all smokers will die as a result of tobacco use including upward of six million people each year. Out of the global impact of smoking-related fatalities, 600,000 have been attributed to non-smokers who were exposed to second-hand smoke. Approximately, 80 percent of the estimated one billion smokers around the world live in low- and middle- income countries. Countries who have implemented bans on tobacco advertising, promotion, and sponsorship have decreased tobacco consumption by seven percent in some countries and 17 percent in others.

Researchers from Spain, France, and the U.S. estimated the potential health impact of the WHO’s proposal using the SimSmoke Tobacco Control Policy model, an international record of smoking prevalence and smoking-related deaths. Researchers said, in a press release, implementing the guidelines set forth by the WHO “would lead to as much as a 34% relative reduction in male smoking prevalence by 2020, and a 41% reduction by 2050.” If the WHO guidelines are ignored, China can expect an additional 50 million smoking-related deaths between 2015 and 2050.

Following the application of smoke-free air laws and tobacco marketing bans have showed “potent and immediate” effects in other countries. Implementing smoke-free air laws in China could reduce smoking rates by nine percent in 2015. Furthermore, increasing increase taxes by 75 percent could also reduce the number of smokers by 10 percent of both males and females by 2015. By 2015, the number of smoking-related deaths was expected at 932,000 men and 79,000 women.

When 2050 finally rolls around, the research team expects the number of female smokers in China to reduce by 12 percent and male smokers by 13 percent. Between 2015 and 2050, researchers expect that WHO guidelines will save 3.5 million lives. A complete ban on tobacco marketing could help reduce smoking by four percent in China. The research team was also confident that “without the implementation of the complete set of stronger policies, the death and disability legacy of current smoking will endure for decades in China.”

When 2050 finally rolls around, the research team expects the number of female smokers in China to reduce by 12 percent and male smokers by 13 percent. Between 2015 and 2050, researchers expect that increasing tobacco sales will save 3.5 million lives. Combine that with smoke-free air campaigns and China could see a reduction in 13 million deaths by the year 2050. A complete ban on tobacco marketing could help reduce smoking by four percent in China. The research team was also confident that “without the implementation of the complete set of stronger policies, the death and disability legacy of current smoking will endure for decades in China.”

Source: Medical Daily


Apple Cider Vinegar as a Remedy and Cosmetic for the Skin

Apple cider vinegar has a long history of cosmetic use. It is a restorative tonic for the skin, improving blood circulation to the capillaries that feed the skin and deliver oxygen, toning, maintaining elasticity, purifying and revivifying. It is a natural
anti-fungal and an antiseptic. Vinegar can have a positive effect on acne and itchy skin conditions such as those due to eczema or sunburn and eliminating fungal infections, warts and skin tags.

Apple cider vinegar is made by crushing fresh apples and allowing them ferment. The best quality apple cider vinegar is made with organic apples, allowed to mature in wooden barrels and retains the “mother,” which is a natural sediment. Apple cider vinegar
should be a little cloudy with a rich amber color.

Apple cider vinegar contains natural enzymes, vitamins and minerals and is rich in antioxidants. It contains Vitamins A, B and C, beta carotene, bioflavonoids, calcium, magnesium, potassium, phosphorus, copper, iron, sulfur, iron, fluorine, silicon, boron
and pectin. It naturally balances the pH balance of the skin and the entire body.

Apple cider vinegar boosts the immune system, fights bacterial infections and reduces inflammation. It makes an excellent astringent, even for sensitive or oily skin.

It can be used both externally and internally to benefit the skin. To use apple cider internally, drink approximately three tablespoons, twice per day.

Since apple cider vinegar has a very strong taste, many people add honey or dilute it with water. Alternatively, some people prefer to take apple cider vinegar in capsule form.

There are many ways to use apple cider vinegar externally. Since it is a natural anti-inflammatory and anti-bacterial it is an excellent choice for fighting mild to severe acne. After your normal cleansing procedure, use a mixture of one part apple cider vinegar to one part water as an astringent. Gently dab it onto the skin with a cotton ball and let it dry naturally.

To remove skin tags, apply apple cider vinegar to the area three times per day. Bandage it and allow it to remain on the skin tag for, at least, fifteen minutes. Repeat this procedure until the tag falls off. Take care using apple cider vinegar near the eyes or
other sensitive areas of the body.

To remove common warts with apple cider vinegar, soak a cotton all with apple cider vinegar and apply it to the affected area. Apply a bandage to keep it in place. Change the bandage, at least, once per day. You may notice that the area begins to itch or burn
a little, but do not be alarmed. The wart may turn black in a few days before falling off. Continue the treatment for three or four days after the wart is gone to prevent it from returning.

To treat skin affected by sunburn, psoriasis or other itchy skin condition, apply diluted apple cider vinegar to the affected areas using a cloth, cotton balls or gauze.   Dilute the apple cider vinegar, one part of apple cider vinegar to approximately six
parts of water.

Alternatively, you can treat skin conditions by adding apple cider vinegar to a bath. To bolster its healing properties, add herbs to create your own vinegar bath and skin tonic.

The following is a basic remedy that you can work from and modify to suit your own tastes:

Heat a quart of vinegar. Add 1/2 cup or a little more chopped herbs, either fresh or dried. Store this mixture in a jar with a secure lid.

If possible, keep it in a warm place away from direct ultra violet rays. Shake the bottle twice per day for two weeks

At the end of two weeks, strain the mixture using a sieve or a coffee filter.

If you have a particularly attractive bottle that you like, place a sprig of herb inside the bottle. Tie a ribbon around the neck of the bottle and you have a decorative bath item or a gift.

Suggested herbs:

Especially for itchy skin: Combine a combination of calendula, comfrey and red clover
tops.

For tired skin: Combine lavender and rosemary.

To promote skin elasticity: Combine lemon grass and geranium.

Add 1/4 to 1/2 cups of vinegar to a bath.

Splash your herbal vinegars on your skin as a healing and firming tonic.

Without a doubt, apple cider vinegar is one of the most effective and versatile skin
remedies. It is also has valuable properties as a cosmetic for the skin. It is also
extremely economical and has many other applications to health and beauty.

Source: Native Natural Remedies


Extra weight may add to elderly fall risk

For Australians over age 65 included in a new study, being obese raised the risk of experiencing a fall by 31 percent.

“Falls are one of the most common causes of injury for older individuals and as the world population ages, the number of fall-related injuries are projected to increase rapidly,” said lead author Rebecca Mitchell.

“Likewise, rates of overweight and obesity among older individuals are also increasing,” added Mitchell, a researcher with Neuroscience Research Australia at the University of New South Wales.

Mitchell and her colleagues wanted to determine whether overweight and obesity added to the risk of falling among older adults, as well as the risk of being injured in a fall.

The researchers used information from the New South Wales Prevention Baseline Survey, a large Australian population study started in 2009.

A total of 5,681 people 65 years of age and older were asked about their history of falling, their perception of their own risk of falling, their general health status, medication use and activity levels.

Participants who had fallen one or more times in the previous 12 months as a result of accidentally losing their balance, tripping or slipping were also asked how many of those falls resulted in injury and how many required medical attention or led to hospital admission.

According to the results published in the Australian and New Zealand Journal of Public Health, 23 percent of healthy-weight respondents had fallen once during the previous 12 months and 34 percent had fallen more than once.

About 30 percent of obese respondents fell once and another 45 percent fell more than once, making the overall fall risk 31 percent higher in the obese group.

The obese participants who fell didn’t have any higher risk of fall-related injuries compared to healthy-weight people who fell, but they were more likely to have other health conditions – such as heart disease, diabetes and high blood pressure – and to report being in moderate or extreme discomfort.

Those who were obese and fell were also more likely to be taking four or more prescription medications.

“It is difficult to know for certain why the risk of falling increases for obese individuals, but it is likely to be as a result of reduced peripheral sensation, general physical weakness and instability when standing or walking,” Mitchell said.

There are a number of common risk factors that can increase any older person’s risk of falling, she added.

“These can include individual factors such as: poor health, instability when standing or walking, some health conditions, such as poor vision or dementia, lack of physical activity, use of multiple medications that can affect balance, and a poor diet,” Mitchell said.

Risks can also be in an older person’s environment, including “uneven or slippery floors, unsecured floor coverings, such as rugs, inappropriate footwear or eyewear, or inadequate lighting,” she said.

“As to why fall-related injuries do not increase for obese individuals this is likely to be as a result of adipose tissue (fat) protecting bone,” Mitchell said.

Compared to the healthy-weight group, the obese participants in the study were more likely to be sedentary for eight or more hours a day, to walk less, to have problems walking and to believe that nothing could be done to prevent falls.

Mitchell and her colleagues point out that obesity is associated with a higher risk of certain chronic illnesses, but also that chronic conditions such as lung disease and arthritis can limit activity, leading to weight gain.

To reduce the risk of falls among obese older people, tailored activity programs, such as strength and balance training, as well as home safety assessments and eyesight checks could all be of benefit, they write.

“Everybody knows how falls can be life-changers for older people, from breaking a hip to hitting your head, so if we can prevent them that’s always better and there’s a lot that can be done,” Dr. Sharon Brangman told Reuters Health.

Brangman, who is Chief of Geriatrics at SUNY Upstate University Hospital in Syracuse, New York, and a past president of the American Geriatric Society (AGS), was not involved in the new study.

“We know that when people fall, the biggest problem afterwards is a fear of falling because then they move less or when they walk they hold themselves really rigid and tight which actually increases the risk for falling,” Brangman said.

The American Geriatric Society published fall prevention guidelines for physicians in 2012, she noted. Though they are intended for doctors, some of the suggestions may help families assess the risk in their homes (see: bit.ly/1cWjB86).

According to the U.S. Centers for Disease Control and Prevention, about one of every three Americans over age 65 suffers a fall, and every year 2 million of those falls result in emergency room visits.

The AGS guidelines were intended to encourage healthcare providers to ask about falls, according to Brangman, “because a lot of times it’s not asked and patients don’t volunteer it because they don’t want anyone to know. They’re so afraid that will mean they need to be placed in long-term care or something.”

Brangman said that sometimes patients who are overweight might need a little extra support to realize that their situation isn’t hopeless and that there are things they can do, such as starting an exercise program.

Strengthening the quadriceps muscle group at the front of the thighs is especially recommended.

“Exercise programs that are tailored to the individual can make a difference, and it’s really never too late to start doing something,” Brangman said. “Balance and strengthening exercises, especially exercises that strengthen the quads, are very important in preventing falls in the future.”

Source: US Web Daily