Brain disorders

Mental illness: Could brain size be a risk factor?

admin

brain

A study published in the journal PLOS Biology could explain why large brains are more vulnerable to brain disorders such as schizophrenia and Alzheimer’s disease.

Mammals exhibit an extensive range of brain sizes, reflecting their adaptation to the varied environments in which they live.

The cerebral cortex in all mammals is the thin layer of gray matter – neural tissue of the brain that is composed of nerve cell bodies and nerve fibers – that covers the brain.

Gray matter is responsible for processing information in the brain, including thoughts, high-level brain functions, such as storing and retrieving memories, calculating, language, and consciousness.

Comparing the cortical networks in the brains of mammals of differing sizes provides data on what features of the brain are preserved through evolution and what processing structures are unique to a particular species.

Zoltán Toroczkai, from the University of Notre-Dame, IN, Mária Ercsey-Ravasz, from Babes-Bolyai University, Romania, and Henry Kennedy, from the University Lyon, France, and colleagues previously combined tracing studies in macaques (which visualize connections in the brain) with network theory. The results showed that macaques’ cortical network is regulated by the exponential distance rule (EDR).

EDR describes a consistent relationship between distances and connection strength. EDR predicts that there are fewer long-range axons than short axons.

Although comparing cortical networks across species can be problematic, the researchers found that by using area tracing data from a macaque, a mammal with a large cortex, and a mouse, which has a significantly smaller cortex, they could introduce a standard model framework that enabled them to make comparisons.

The team used a general organization principle – based on an EDR and cortical geometry – to carry out comparisons within the same model framework.

Regardless of the differing cortex size between species and cortex organization, the researchers noted that all the statistical features of all cortical networks followed EDR.

Long-range connections weaker in primates’ brains than rodents’

In terms of the cortical areas examined by the tracing studies – such as visual cortex or auditory cortex – the closer the two areas were together, the more connections there were between them.

Although the cortical networks in primates and rodents are similar, the long-distance connections in the primates’ brains were considerably weaker.

Source: http://www.medicalnewstoday.com/articles/311844.php

Texting at night affects teens’ sleep, academic performance

Can’t stop texting? If you’re a teenager, it may be to blame for falling grades and increased yawning in school, according to a new Rutgers study.

The study, published in the Journal of Child Neurology, is the first of its kind to link nighttime instant messaging habits of American teenagers to sleep health and school performance.

“We need to be aware that teenagers are using electronic devices excessively and have a unique physiology,” says study author Xue Ming, professor of neuroscience and neurology at Rutgers New Jersey Medical School. “They tend to go to sleep late and get up late. When we go against that natural rhythm, students become less efficient.”

The American Academy of Pediatrics reports that media use among children of all ages is increasing exponentially; studies have found that children ages 8 to 18 use electronic devices approximately seven-and-a-half hours daily.

Ming’s research is part of a small but growing body of evidence on the negative effects of electronics on sleep and school performance. But few studies, Ming says, have focused specifically on instant messaging.

“During the last few years I have noticed an increased use of smartphones by my patients with sleep problems,” Ming says. “I wanted to isolate how messaging alone – especially after the lights are out – contributes to sleep-related problems and academic performance.”

To conduct her study, Ming distributed surveys to three New Jersey high schools – a suburban and an urban public school and a private school – and evaluated the 1,537 responses contrasting grades, sexes, messaging duration and whether the texting occurred before or after lights out.

She found that students who turned off their devices or who messaged for less than 30 minutes after lights out performed significantly better in school than those who messaged for more than 30 minutes after lights out.

Students who texted longer in the dark also slept fewer hours and were sleepier during the day than those who stopped messaging when they went to bed. Texting before lights out did not affect academic performance, the study found.

Although females reported more messaging overall and more daytime sleepiness, they had better academic performance than males. “I attribute this to the fact that the girls texted primarily before turning off the light,” Ming says.

The effects of “blue light” emitted from smartphones and tablets are intensified when viewed in a dark room, Ming says. This short wavelength light can have a strong impact on daytime sleepiness symptoms since it can delay melatonin release, making it more difficult to fall asleep – even when seen through closed eyelids.

“When we turn the lights off, it should be to make a gradual transition from wakefulness to sleep,” Ming says. “If a person keeps getting text messages with alerts and light emission, that also can disrupt his circadian rhythm. Rapid Eye Movement sleep is the period during sleep most important to learning, memory consolidation and social adjustment in adolescents. When falling asleep is delayed but rising time is not, REM sleep will be cut short, which can affect learning and memory.”

Ming notes some benefits to early-evening media use, such as facilitating collaboration for school projects, providing resources for tutoring, increasing school readiness and possibly offering emotional support systems.

She suggests that educators recognize the sleep needs of teenagers and incorporate sleep education in their curriculum. “Sleep is not a luxury; it’s a biological necessity. Adolescents are not receiving the optimal amount of sleep; they should be getting 8-and-a-half hours a night,” says Ming. “Sleep deprivation is a strong argument in favor of later start times for high schools – like 9 a.m.”

Source: Sciencedaily

Alzheimer’s disease may kill as many as cancer in US

Deaths from Alzheimer’s disease are under-reported in the United States and the most common form of dementia may be taking as many lives as heart disease or cancer.

Alzheimer’s disease currently ranks sixth among causes of death in the United States, according to the Centers for Disease Control and Prevention. Heart disease is first, and cancer second.

But researchers reported in the journal Neurology, the medical journal of the American Academy of Neurology, that Alzheimer’s-linked deaths could be six times more common than thought.

“Alzheimer’s disease and other dementias are under-reported on death certificates and medical records,” said study author Bryan James of Rush University Medical Center in Chicago.

“Death certificates often list the immediate cause of death, such as pneumonia, rather than listing dementia as an underlying cause.”

For the study, researchers followed more than 2,500 people aged 65 and older who were tested annually for dementia.

A total of 559 participants developed Alzheimer’s disease during the course of the study, and the average time span from diagnosis to death was four years.

People aged 75 to 84 who were diagnosed with Alzheimer’s were also four times more likely to die than those without it.

One third of all deaths among those aged 75 and older were attributable to Alzheimer’s disease, said the study.

According to James, the findings would translate to an estimated 503,400 deaths from Alzheimer’s in the US population over age 75 in 2010.

That figure is six times higher than the 83,494 reported by the CDC based on death certificates.

“Determining the true effects of dementia in this country is important for raising public awareness and identifying research priorities regarding this epidemic,” said James.

Source: Channel news asia