Mental Health

Alcohol-Related Brain Damage

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It’s hardly a secret that alcohol affects the brain — its initial effects include wobbly walking, blurred vision, and slurred speech. But although drinking in moderation isn’t necessarily harmful, and can even help with creativity, researchers in the UK are warning that the long-term effects of drinking may go further than the liver, affecting the brain in more permanent ways.

The report, “All in the Mind,” from Alcohol Concern Cymru, a charity based in London, is a supposed “wake up call” for both the public and health care providers. It highlights the dangers of alcohol-related brain damage (ARBD), an umbrella term for a range of conditions resulting from long-term drinking. These include confusion, poor concentration, memory loss, and depression, as well as other issues that may arise from drinking, like traumatic brain injuries (from falling while drunk) and ophthalmoplegia — a weakness or paralysis of the eye.

Many of these problems are also characteristics of a disease known as Wernicke-Korsakoff syndrome (WKS), a debilitating and long-lasting syndrome that actually consists of two separate conditions, according to the National Institutes of Health. One of them, known as Wernicke’s encephalopathy, is defined by mental confusion, eye paralysis, and problems with muscle coordination — oftentimes not altogether. Korsakoff’s psychosis is the other condition, characterized by persistent learning and memory problems.

“Most of us know that alcohol can damage our liver, but the fact that it could undermine our long-term brain function is much less well-known,” said Andrew Misell, director of Alcohol Concern Cymru, in a statement. “And when alcohol-related brain damage is on the radar, the focus is often on older street drinkers. But staff on the frontline have been seeing younger people, and other people who don’t fit the stereotype of a homeless dependent drinker, coming in with ARBD. … We hope this paper will be a wake-up call for all of us who drink.”

Alcohol Concern says that while moderation is key, many people instead go through periods during which they drink heavily, then abstain. The charity notes that vitamin deficiency is a major contributor to ARBD — 80 percent of alcoholics are vitamin deficient — and suggests increasing intake of vitamin B1, also called thiamine, which can be given through injections or pills

Source: medical daily

Inability to enjoy music recognized as a brain condition

For most people, music is one of life’s great pleasures. But the inability to enjoy it is a real condition that has just been recognized and described by science.

The new condition, known as specific musical anhedonia, is described in a new paper published this week in the journal Current Biology.

People with the condition have no trouble perceiving or identifying music, or even describing the mood the music is supposed to convey, said Robert Zatorre, a McGill University neuroscientist who co-authored the paper.

“They had no trouble saying, ‘Oh, well, this music is meant to be melancholy. This music is meant to be really happy.’ But they don’t experience it,” he told CBC’s Quirks & Quarks in an interview that airs Saturday. “They know that’s what it’s supposed to do for you. But they get no sensation out of it.”

He estimated that the condition affects about two per cent of the population. Many of those who have it said they have tried to mask their dislike of music from others.

“It’s sort of socially odd, right? Everyone wants to fit in and if they went to a party and there was music blaring, they would kind of go along with it and try to pretend that they liked it as much as everyone else did.”

Zatorre had previously done studies that showed music activates the pleasure and reward centres of the brain, just as food and sex do.

Scientists are interested in studying the brain’s reward system because problems with it are implicated in a lot of problems such as eating disorders and drug and gambling addictions.

Zatorre and colleagues in Spain, including Josep Marco-Pallares of the University of Barcelona, began to wonder if music activated the pleasure centre of the brain in everyone, or if there were some people who didn’t respond the same way.

Physiological response

To figure that out, they surveyed around 500 students at the University of Barcelona about their music habits and response to music — for example, did they often have music playing and did they like to share music with their friends?

Groups of students who scored high, average, and low on the questionnaire were tested in the lab for their body’s response to music — changes in heart rate and skin conductance, which indicate emotional or nervous system arousal.

While those who scored average or high on the questionnaire had a strong physiological response to the music, those who scored low “more or less flatlined,” Zatorre recalled, confirming that they did not derive pleasure from music.

The students were given additional questionnaires to make sure they weren’t depressed and were able to experience pleasure from other things.

Then they were tested in another experiment – a slot-machine-like gambling video game in which they would sometimes receive a big payout.

“People who didn’t respond to music nonetheless showed a perfectly normal response to the monetary reward,” Zatorre said.

That’s interesting because previously, researchers had thought the brain’s reward centre was an “all or none” system that was functioning normally, hyperactive, or underactive as a whole.

The new research suggests that the brain’s reward centre may react differently to different kinds of stimuli. That in turn has implications for the way researchers approach problems like drug addiction or eating disorders.

Source: cbc news

Switching Schools May Give Your Kids Psychotic Symptoms

Changing schools can be a wrenching social and emotional experience for students, say researchers from Warwick Medical School in the U.K. And the legacy of that struggle may be psychosis-like symptoms of hallucinations and delusions.

Dr. Swaran Singh, a psychiatrist and head of the mental health division at Warwick, became curious about the connection between school moves and mental health issues after a study from Denmark found that children moving from rural to urban settings showed increased signs of psychoses. The authors also noted that the students had to deal with not just a change in their home environment, but in their social network of friends at school as well.

Singh was intrigued by whether school changes, and the social isolation that comes with it, might be an independent factor in contributing to the psychosis-like symptoms.

Working with a database of nearly 14,000 children born between 1991 and 1992 and followed until they were 13 years old, Singh and his colleagues investigated which factors seemed to have the strongest effect on mental health. The children’s mothers answered questions about how many times the students had moved schools by age nine, and the children responded to queries about their experiences either bullying others or being victims of bullying. The survey even included a look at the children’s in utero environments, and their circumstances from birth to age 2, by asking the mothers about where they lived (in urban or village areas, for example), and about financial difficulties or other family social issues.

Based on their analysis, says Singh, switching schools three or more times in early childhood seemed to be linked to an up to two-fold greater risk of developing psychosis-like symptoms such as hallucinations and interrupting thoughts. “Even when we controlled for all things that school moves lead to, there was something left behind that that was independently affecting children’s mental health,” he says.

Factors such as a difficult home environment – whether caused by financial or social tension, or both – living in an urban environment, and bullying contributed to the mental health issues, but switching schools contributed independently to the psychosis-like symptoms.

Singh suspects that repeatedly being an outsider by having to re-integrate into new schools may lead to feelings of exclusion and low self-esteem. That may change a developing child’s sense of self and prime him to always feel like an outlier and never an integrated part of a social network; such repeated experiences of exclusion are known to contribute to paranoia and psychotic symptoms.

Bullying created a secondary way in which repeated school moves could lead to mental health issues — bullying is known to be associated with psychotic symptoms, and mobile students are more vulnerable to bullying,

The negative emotional experiences students go through in trying to adjust to new schools can have physiological consequences as well. “Repeated experiences of being defeated in social situations leads to changes in the brain and in the dopaminergic system,” says Singh. That makes the brain more sensitive to stress, and stress, with its surges of cortisol, can lead to unhealthy neural responses that can contribute to mental health problems. “Something about chronic marginalization, and chronic exclusion, is neurophysiologically damaging,” he says.

Source: health and time

Solitary confinement: A man lives 29 years in a box

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Robert King still remembers well the dimensions of his cell: 6 x 9 x 12 feet. There was a steel bed and a sink that doubled as a toilet where he would also wash clothes.

King spent 29 years in solitary confinement in Louisiana. He has been free since 2001, but still has difficulty with geographical orientation.

“I get confused as to where I am, where I should be,” he said.

King joined researchers and legal experts at the American Association for the Advancement of Science annual meeting in Chicago this month to talk about the mental and physical health consequences of solitary confinement.

“The widespread consensus among mental health professionals is that solitary confinement, for the overall majority of mentally ill prisoners, places them at severe risk of additional harm,” said Craig Haney, director of the program in legal studies at the University of California, Santa Cruz.

The talk was timely. This week, New York state agreed to several changes that would limit the use of solitary confinement for disciplining some groups of inmates, including those under 18 or pregnant women. The agreement stemmed from a class-action lawsuit.

The New York State Department of Corrections provided to CNN a statement from its acting commissioner, which read in part: “These are important reforms that will make the disciplinary practices in New York’s prisons more humane, and ultimately, our state’s criminal justice system more fair and progressive, while maintaining safety and security.”

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A department spokesperson said no statement was available on the general use of solitary confinement.

A brief history of solitary confinement
There are about 80,000 people being held in some sort of solitary-type confinement in the United States, Haney said.

Prisoners in solitary confinement tend to be restricted to cells of 80 square feet, not much larger than a king-size bed, Haney said. Sleeping, eating and defecating all take place inside that space. For exercise, prisoners in solitary confinement often get a short time in a cage rather than an outdoor yard — perhaps one hour per day.

Haney, who has studied prisons and punishment for more than four decades, estimates that about one-third of people in solitary confinement in this country are mentally ill, although some prison systems do not permit mentally ill inmates to be placed in solitary confinement.

Solitary confinement was used broadly in the 19th century, but the punishment was then largely abandoned because of the view that “it was doing more harm than good,” Haney said.

Correctional practice began to reincorporate solitary confinement in the late 1970s and 80s, as prisons began to get overcrowded, Haney said. He believes prison systems turned to solitary confinement as a short-term solution to controlling disruptive or violent behavior, lacking the resources to provide positive incentives or programming.

But overcrowding in prisons turned out to be permanent and mostly increased each year.
Prison systems continued to struggle over what to do to resolve conflicts or stop violence or disruption in the institutions. They put more prisoners in solitary confinement and left them there for longer periods of time, Haney said.

“I think the cost of solitary confinement is now being critically examined and rethought, and prison systems are beginning to ask themselves whether this is worth it, and whether or not it does not create more harm than good,” he said. “Courts are pushing them to consider the inhumanity of the practice, as well.”

Source: CNN news

Stress Linked to Headache Frequency

German researchers have confirmed what headache sufferers have long suspected: The more stressed out you are, the more frequent your headaches.

For being so common, the exact mechanisms behind headaches can be somewhat mysterious. While the new data can only suggest an association with stress, “I would think that stress ‘triggers’ headache,” one of the researchers, Dr. Zaza Katsarava of University Hospital, University of Duisburg-Essen, told.

The study used data from the German Headache Consortium Study of 5,159 people age 21-71. These people answered questionnaires every three months from 2010 to 2012 about headache type and frequency and used a visual 100-point scale to state how much stress they experienced.

After adjusting for age, sex, drinking habits, smoking and so on, the data was clear. For those who reported “tension” headaches, each 10 point increase in stress was associated with a 6.3 percent increase in the number of days each month they suffered through a headache.

Migraine and mixed tension-migraine sufferers also showed increases with stress, 4.3 and 4 percent respectively, though Katsarava cautioned that because headache type was self-reported, some people who said they had migraines might have had tension headaches.

Those results jibe with other studies, like one from Ohio’s Xavier University released last spring in which researchers from the business school found that headache-related hospital admission increased significantly during the 2008-2009 recession.

Alleviating stress can be especially important for people who experience headaches, Katsarava said, because stress can create a vicious cycle. “Stress triggers headache, headache triggers stress. Because people are disabled, they can not manage their life and their duties.”

Headache treatment, she argued, should be include medical, psychological and behavioral approaches.

Source: nbc news

Challenge at Work May Ease Adults’ Autism Symptoms

For adults with autism, having the chance to work somewhat independently may lead to a reduction in symptoms of the disorder, a new study suggests.

The research puts new emphasis on the potential for adults with autism to develop and improve over their lifetimes, said study author Julie Lounds Taylor, an assistant professor of pediatrics at Vanderbilt University, in Nashville.

“We have assumed it’s really hard to budge autism symptoms in adulthood. Drugs are targeted to problems like acting out, for example,” she said. “But this study suggests that these adults need a place where they’re intellectually stimulated, and then we’ll see a reduction in symptoms.”

The challenge is to find the right fit between a person’s abilities and interests and a specific job, she explained.

“How independent can they be and what are the risks of failure? We have to be careful. You’re talking about a huge range of people with autism,” Taylor said. “I’ve seen people who can manage pretty high-level jobs, like computer programming or being in the military, while others have more [mental] challenges, but can still work a job in the community with support.”

Autism spectrum disorders are a class of neurodevelopmental disorders defined by difficulties with social functioning and communication, according to the researchers. Symptoms include restricted interests, repetitive behaviors and difficulty with social interactions.

The study findings were reported online recently in the Journal of Autism and Developmental Disorders.

Increasing the level of independence in adults with autism isn’t necessarily difficult to do, Taylor said. “We found behavior changes any time you could bump [them] up to doing something a little more independent,” she said. “As they get more independent, you see more benefit.”

Yet understanding what makes a good fit is a huge challenge, she said. “Insight is one of the characteristics people with autism typically may not have, so we will probably need the person’s perspective and then gather information from families, looking at what’s available, and incorporating all of that together,” Taylor explained.

About 50 percent of adults with autism spend their time in sheltered settings, and a minority work in the community, according to Taylor. Most have trouble holding steady jobs, she added.

For the study, the researchers tracked the behavioral development and activities of 153 people with autism spectrum disorder over a five-year period. Their average age was about 30.

The data came from a larger study conducted at the University of Wisconsin-Madison, which followed 400 families with adolescents with autism over 10 years. Data were collected at two different points in time almost six years apart. Data came from the primary caregiver — 150 were mothers and three were fathers.

The researchers found that having greater vocational independence and engagement was related to reduction in autism symptoms and maladaptive behaviors. It was also associated with improvements in daily life activities.

An expert in autism spectrum disorders who was not involved in the study said the results were not surprising.

“This study suggests that, as with nondisabled individuals, a more positive work experience can have many important associated benefits downstream,” said Dr. Andrew Adesman, chief of developmental and behavioral pediatrics at Steven & Alexandra Cohen Children’s Medical Center of New York, in New Hyde Park.

If the research can be replicated, Adesman said it suggests greater emphasis needs to be given to helping adults with autism spectrum disorder find as independent and engaging a work environment as possible.

Taylor said the key point for parents of adults with autism spectrum disorder is to understand the value of getting the best possible vocational placement for their son or daughter and advocating for it.

“If it’s a terrible fit, in ability or in what interests them, it won’t work out,” she said. “But a job can have lasting behavioral impact across the lifespan.”

Source: Web md

How sleep duration can up depression risk

A genetic study of adult twins and a community-based study of adolescents have linked sleep duration with depression.

“Healthy sleep is a necessity for physical, mental and emotional well-being,” American Academy of Sleep Medicine President Dr. M. Safwan Badr, said.

“This new research emphasizes that we can make an investment in our health by prioritizing sleep,” Badr said.

A study of 1,788 adult twins is the first to demonstrate a gene by environment interaction between self-reported habitual sleep duration and depressive symptoms.

Results suggest that sleep durations outside the normal range increase the genetic risk for depressive symptoms.

Among twins with a normal sleep duration of seven to 8.9 hours per night, the total heritability of depressive symptoms was 27 percent.

However, the genetic influence on depressive symptoms increased to 53 percent among twins with a short sleep duration of five hours per night and 49 percent among those who reported sleeping 10 hours per night.

“We were surprised that the heritability of depressive symptoms in twins with very short sleep was nearly twice the heritability in twins sleeping normal amounts of time,” principal investigator Dr. Nathaniel Watson, associate professor of neurology and co-director of the University of Washington Medicine Sleep Center in Seattle, said.

“Both short and excessively long sleep durations appear to activate genes related to depressive symptoms ,” Watson, who also serves on the board of directors of the American Academy of Sleep Medicine, said.

According to Watson, the study suggests that optimizing sleep may be one way to maximize the effectiveness of treatments for depression such as psychotherapy.

Another study of 4,175 individuals between 11 and 17 years of age is the first to document reciprocal effects for major depression and short sleep duration among adolescents using prospective data.

Results suggest sleeping six hours or less per night increases the risk for major depression, which in turn increases the risk for decreased sleep among adolescents.

The studies are published in the journal Sleep.

Source: The siasat Daily

Unique brain area that makes us human identified

Oxford University researchers have identified an area of the human brain that is known to be intimately involved in some of the most advanced planning and decision-making processes that we think of as being especially human.

“We tend to think that being able to plan into the future, be flexible in our approach and learn from others are things that are particularly impressive about humans. We’ve identified an area of the brain that appears to be uniquely human and is likely to have something to do with these cognitive powers,” senior researcher Professor Matthew Rushworth of Oxford University’s Department of Experimental Psychology said.

MRI imaging of 25 adult volunteers was used to identify key components in the ventrolateral frontal cortex area of the human brain, and how these components were connected up with other brain areas. The results were then compared to equivalent MRI data from 25 macaque monkeys.

This ventrolateral frontal cortex area of the brain is involved in many of the highest aspects of cognition and language, and is only present in humans and other primates.

Some parts are implicated in psychiatric conditions like ADHD, drug addiction or compulsive behaviour disorders.

Language is affected when other parts are damaged after stroke or neurodegenerative disease.

A better understanding of the neural connections and networks involved should help the understanding of changes in the brain that go along with these conditions.

The findings are published in the science journal Neuron.

Source: Business standard

 

Spanking linked to behaviour problems in kids

Decades of research studies have found that spanking can negatively affect kids, researchers said.

Child psychologist George Holden and three colleagues at Southern Methodist University, Dallas, wanted to see if parents’ positive views toward spanking could be reversed if they were made aware of the research.

Researchers used a simple, fast, inexpensive method to briefly expose subjects to short research summaries that detailed spanking’s negative impact.

Carrying out two studies, one with non-parents and one with parents, Holden and his co-authors on the research found that attitudes were significantly altered.

“Parents spank with good intentions – they believe it will promote good behaviour, and they don’t intend to harm the child. But research increasingly indicates that spanking is actually a harmful practice,” said Holden, lead author on the study.

“These studies demonstrate that a brief exposure to research findings can reduce positive corporal punishment attitudes in parents and non-parents,” Holden said.

The researchers believe the study is the first of its kind to find that brief exposure to spanking research can alter people’s views toward spanking.

“If we can educate people about this issue of corporal punishment, these studies show that we can in a very quick way begin changing attitudes,” said Holden.

In the first study, the subjects were 118 non-parent college students divided into two groups: one that actively processed web-based information about spanking research; and one that passively read web summaries.

The summary consisted of several sentences describing the link between spanking and short- and long-term child behaviour problems, including aggressive and delinquent acts, poor quality of parent-child relationships and an increased risk of child physical abuse.

The majority of the participants in the study, 74.6 per cent, thought less favourably of spanking after reading the summary. Unexpectedly, the researchers said, attitude change was significant for both active and passive participants.

A second study replicated the first study, but with 263 parent participants, predominantly white mothers.

After reading brief research statements on the web, 46.7 per cent of the parents changed their attitudes and expressed less approval of spanking, researchers said.

The findings have been published in the international journal of Child Abuse & Neglect.

Source: Post Jargan

DDT: Pesticide linked to Alzheimer’s

Exposure to a once widely used pesticide, DDT, may increase the chances of developing Alzheimer’s disease, suggest US researchers.

A study, published in JAMA Neurology, showed patients with Alzheimer’s had four times the levels of DDT lingering in the body than healthy people.

Some countries still use the pesticide to control malaria.

Alzheimer’s Research UK said more evidence was needed to prove DDT had a role in dementia.

DDT was a massively successful pesticide, initially used to control malaria at the end of World War Two and then to protect crops in commercial agriculture.

However, there were questions about its impact on human health and wider environmental concerns, particularly for predators.

It was banned in the US in 1972 and in many other countries. But the World Health Organization still recommends using DDT to keep malaria in check.

Not clear
DDT also lingers in the human body where it is broken down into DDE.

The team at Rutgers University and Emory University tested levels of DDE in the blood of 86 people with Alzheimer’s disease and compared the results with 79 healthy people of a similar age and background.

The results showed those with Alzheimer’s had 3.8 times the level of DDE.

However, the picture is not clear-cut. Some healthy people had high levels of DDE while some with Alzheimer’s had low levels. Alzheimer’s also predates the use of DDT.

The researchers believe the chemical is increasing the chance of Alzheimer’s and may be involved in the development of amyloid plaques in the brain, a hallmark of the disease, which contribute to the death of brain cells.

Prof Allan Levey, the director of the Alzheimer’s Disease Research Centre at Emory, said: “This is one of the first studies identifying a strong environmental risk factor for Alzheimer’s disease.

“The magnitude of the effect is strikingly large, it is comparable in size to the most common genetic risk factor for late-onset Alzheimer’s.”

Fellow researcher Dr Jason Richardson added: “We are still being exposed to these chemicals in the United States, both because we get food products from other countries and because DDE persists in the environment for a long time,” .

Dr Simon Ridley, the head of research at the charity Alzheimer’s Research UK, said: “It’s important to note that this research relates to DDT, a pesticide that has not been used in the UK since the 1980s.

“While this small study suggests a possible connection between DDT exposure and Alzheimer’s, we don’t know whether other factors may account for these results.

“Much more research would be needed to confirm whether this particular pesticide may contribute to the disease.”

Source; BBC news