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Young brains and anesthesia: Big study suggests minimal risks

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Anesthesia during early childhood surgery poses little risk for intelligence and academics later on, the largest study of its kind suggests.

The results were found in research on nearly 200,000 Swedish teens. School grades were only marginally lower in kids who’d had one or more common surgeries with anesthesia before age 4, compared with those who’d had no anesthesia during those early years.

Whether the results apply to sicker children who have riskier surgeries with anesthesia is not known. But the researchers from Sweden’s Karolinska Institute and doctors elsewhere called the new results reassuring, given experiments in young animals linking anesthesia drugs with brain damage.

Previous studies of children have been relatively small, with conflicting results. The new findings, published Monday in JAMA Pediatrics , don’t provide a definitive answer and other research is ongoing.

The study authors and other doctors say the harms from postponing surgery must be considered when evaluating any potential risks from anesthesia in young children.

The most common procedures in the study were hernia repairs; ear, nose or throat surgeries; and abdominal operations. The researchers say the operations likely lasted an hour or less. The study did not include children with other serious health problems and those who had more complex or risky operations, including brain, heart and cancer surgeries.

The research involved about 33,500 teens who’d had surgery before age 4 and nearly 160,000 who did not.

School grades at age 16 were less than half a percent lower on average in teens who’d had one childhood surgery with anesthesia versus the no-surgery group. Average grades were less than 2 percent lower among teens who’d had two or more surgeries with anesthesia.

The researchers also looked at IQ tests given to Swedish boys at age 18 upon joining the military. Scores were about the same for those with one early surgery and the non-surgery group; scores were less than 3 percent lower in boys with three or more early surgeries.

The researchers, led by Karolinska’s Dr. Pia Glatz, noted that factors other than anesthesia appeared to have a much greater impact on academics and intelligence measures, including mothers’ education level.

A journal editorial says the results mean it is unlikely that early anesthesia poses a long-term risk. The study is “reassuring for children, parents and caregivers and puts the issue of anesthetic-related neurotoxicity and the developing brain into perspective,” the editorial says.

Source : http://www.foxnews.com/health/2016/11/07/young-brains-and-anesthesia-big-study-suggests-minimal-risks.html

Some immune-boosting cancer drugs may pose rare heart risks

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Doctors have found a disturbing downside to some powerful new drugs that harness the immune system to fight cancer: In rare cases, they may cause potentially fatal heart damage, especially when used together.

“The problem is, no one has this on their radar,” so patients are not routinely checked for it, said Dr. Javid Moslehi, head of a Vanderbilt University clinic specializing in heart risks from cancer therapies.

He led a report Wednesday in the New England Journal of Medicine describing two patients who died of heart trouble two weeks after receiving their first doses of two Bristol-Myers Squibb drugs, Opdivo and Yervoy, for the deadly skin cancer melanoma.

Two similar drugs also are on the market, and the study leaders believe they might pose heart risks, too.

“My sense is that this is a class effect, not limited to one drug,” Moslehi said.

The risks do not negate the huge benefits of these relatively new types of drugs, doctors stress. Called checkpoint inhibitors, they have transformed treatment of several types of cancer by helping the immune system see and attack tumors.

In rare cases, the immune system seems to attack not only the tumor but also the heart and other muscles, causing dangerous inflammation and heart rhythm problems. Patients need to be told of the risks, monitored closely and treated quickly with medicines to quell the immune response if trouble develops.

Besides melanoma, the Opdivo-Yervoy combination is used to treat some lung cancers, though at different doses. Other checkpoint inhibitors include Genentech’s Tecentriq, for bladder cancer, and Merck & Co.’s Keytruda, which former President Jimmy Carter received for melanoma that spread to his brain. Many more are in testing.

There have been occasional, previous reports of heart troubles with these drugs. After the two recent deaths, doctors asked Bristol-Myers to check patient safety records on Opdivo and Yervoy.

As of April, 18 cases of serious heart inflammation were found among 20,594 patients receiving either or both drugs, a rate of 0.09 percent. It was more severe and more common among people on both drugs, affecting 0.27 percent of those patients. Bristol-Myers scientists helped write the journal report, and some other authors consult for the company.

Studies have shown that the drug combination gives a stronger anti-cancer effect than either drug alone, but “we’ve known this is a double-edged sword” because of the risk of over-stimulating the immune system, said Dr. Jeffrey Sosman of Northwestern University in Chicago, who treated the two patients who died.

“The big question is, is there enough advantage to using the combination, which is much more toxic, than a single drug,” he said.

That’s a larger question facing the cancer field, not just with immune therapies. Some of the newer gene-targeting drugs also have produced major side effects when used in combination. Yet many doctors believe that combos may be the best way to get cancer to go into remission and stay there longer, by shutting down multiple pathways the tumor employs at once.

Dr. Michael Atkins, deputy director of the Georgetown-Lombardi Comprehensive Cancer Center, believes the heart problems with checkpoint inhibitors will turn out to be treatable in most patients.

“It just gives us a moment of pause,” said Atkins, who led a study that included one of the two patients who died. “This is a rare event … but it’s a particularly serious one.”

Source: http://www.foxnews.com/health/2016/11/03/some-immune-boosting-cancer-drugs-may-pose-rare-heart-risks.html

Sodas Linked to Gallbladder Cancer

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People who drink lots of soda or other sugary beverages may have a higher risk of developing rare cancers in the gallbladder and bile ducts around the liver, a Swedish study suggests.

Little is known about the causes of biliary tract and gallbladder tumors, but emerging evidence suggests obesity as well as elevated blood sugar levels that are a hallmark of diabetes may increase the risk of these malignancies.

Because sodas and other sugary drinks have been linked to high blood sugar and weight gain, researchers wondered if these beverages might play a role in these types of cancer, said lead study author Susanna Larsson of the Karolinska Institute in Sweden.

To explore this possibility, researchers analyzed survey data on the eating and drinking habits of more than 70,000 adults then followed them for more than 13 years on average to see whether cancers got diagnosed.

Only about 150 people developed biliary tract or gallbladder cancers during the study period.

But compared with people who avoided sugar-sweetened drinks altogether, individuals who consumed two or more juice drinks or sodas, including artificially sweetened sodas, a day had more than twice the risk of developing gallbladder tumors and 79 percent higher odds of getting biliary tract cancer, the study found.

“Soda consumption has been inconsistently associated with risk of biliary tract cancer (only one prior study) and other cancers in previous similar studies,” Larsson said by email.

The current study “is the first study to show a strong link between consumption of sweetened beverages, such as soda, and risk of biliary tract cancer,” Larsson added.

At the start of the study, participants completed food and drink questionnaires that asked how many sodas or juice drinks they had consumed in the past week and how much they typically consumed during the previous year.

When they answered these questions in 1997, participants were 61 years old on average. About half of them were overweight and roughly 25 percent were current smokers.

Researchers excluded people with a previous cancer diagnosis or a history of diabetes.

The people who drank two or more sodas or sugary beverages a day were more likely to be overweight and eat a higher-calorie diet with more sugar and carbohydrates and less protein and fat.

The increased risk of gallbladder and biliary tract tumors persisted, however, even after researchers adjusted for whether participants were overweight.

Because the study is observational, the findings don’t prove soda and sugary drinks cause cancer.

It’s also possible that because researchers only had data on drinking habits at the start of the study, the findings might have been influenced by changes over time in the beverages people consumed, the authors note in JNCI: Journal of the National Cancer Institute.

Researchers also lacked precise data to assess how often the drinks people chose were diet sodas, said Dr. Margo Denke, a former researcher at the University of Texas Southwestern Medical School in Dallas who wasn’t involved in the study.

Even so, “this study suggests that there is more than a plausible link; the incidence of biliary and gall bladder cancer was higher among individuals who consumed more sodas and juices,” Denke said by email.

The exact reasons for the connection between sodas and these tumors may be unclear, but the message for consumers is still simple, said Dr. Igor Astsaturov, a medical oncologist at Fox Chase Cancer Center in Philadelphia who wasn’t involved in the study.

“Obviously, this finding signals again and again that healthy lifestyle is the key to cancer-free life,” Astsaturov said by email. “Regardless of the cause, it is easy enough to quench the thirst with water to stay fit and healthy.”

Source: http://www.nbcnews.com/health/health-news/sodas-linked-gallbladder-cancer-n608716

Michael Bloomberg named World Health Organization ambassador

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health minister

The World Health Organization has appointed billionaire philanthropist and former New York mayor Michael Bloomberg as a global ambassador to help spur governments and donors to tackle prevalent diseases such as cancer, diabetes and heart and lung disease.

WHO Director General Margaret Chan said in Wednesday’s announcement that she was “absolutely delighted” that he will be WHO’s Global Ambassador for Non-communicable Diseases.

She cited Bloomberg’s longtime support for WHO efforts to control smoking and tobacco use, improve road safety and prevent drowning.

Chan said Bloomberg will help mobilize global action to prevent and treat non-communicable diseases and combat injuries, which together account for almost 80 percent of deaths worldwide.

Bloomberg expressed excitement that by replicating effective measures globally, “we can save many millions of lives.”

Source: http://www.foxnews.com/health/2016/08/17/michael-bloomberg-named-world-health-organization-ambassador.html

How to reverse the health risks of sitting all day

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sitting in office

Sitting too much can take a serious toll on your health, even raise your risk of early death. But if you’re stuck in your chair at a desk job all day, don’t despair — a new study suggests there is something you can do to reverse the damage.

It comes down to fitting in an hour of walking or other physical activity a day. It doesn’t have to be a super-intense fitness routine to offer benefits, say the authors of a new study.

Researchers from the Norwegian School of Sports Sciences in Oslo, Norway, and the University of Cambridge in the U.K. analyzed data on more than one million people drawn from 16 different studies. Their goal was to find out how many hours of physical activity would be needed to counteract the negative health effects of sitting on your tush all day at the typical eight-hour-a-day office job.

Most of the people studied were over 45 and from the U.S., Western Europe and Australia. The scientists divvied up data on them into four groups according to how active they were, ranging from those who were in motion less than five minutes a day to those who were able to fit in 60 to 75 minutes of physical activity per day. Their activities included brisk walking (at about a 3.5 mph pace) or cycling for pleasure (at almost a 10 mph pace).

The increased risk of death linked with sitting for eight hours a day was eliminated for people who were physically active for at least one hour a day.

What’s more, the eight-hour-a-day sitters who exercised had a significantly lower risk of death compared to people who sat for fewer hours a day but weren’t active, the authors found.

Those who sat for most of the day were at the highest risk for death.

The researchers say what they found was a simple recipe for better health. “Our message is a positive one: it is possible to reduce – or even eliminate – these risks if we are active enough, even without having to take up sports or go to the gym,” the study’s lead researcher, Ulf Ekelund, of the Norwegian School of Sport Sciences, said in a statement.

But he noted that, unfortunately, only 25 percent of the people in the study exercised one hour a day or more.

This is just the latest research to look at the health issues raised by sedentary lifestyles. A study out last year in the Annals of Internal Medicine showed less rosy results. It found sitting for prolonged periods of time increased the risk for heart disease, diabetes, cancer and early death even in people who got half an hour to an hour of exercise a day. It found sitting for prolonged periods raised the risk of cardiovascular disease by 14 percent, cancer by 13 percent, and diabetes by a whopping 91 percent.

Another 2014 study in Mayo Clinic Proceedings found that prolonged sitting affected people’s fitness levels, regardless of whether they exercised or not. Two hours of sitting cancelled out the benefits of 20 minutes of exercise when it came to cardio-respiratory fitness, the authors said.

Heart expert Dr. Suzanne Steinbaum, a preventive cardiologist at Lenox Hill Hospital in New York City, said any exercise is good for you. It can improve cardiovascular health and help fend off health problems such as diabetes and obesity.

“Our lives have become so sedentary. Often people’s sitting time is significantly more than eight hours a day,” said Steinbaum, who noted that the size of the latest study makes its findings especially significant.

“I love this study because it really is showing that we can do something. There were a lot of people involved. It shows how relevant exercise is in our lives. It’s no longer a leisure activity, and it’s not just a treat to get a workout in, it’s not an option not to. It’s something we have to put in our lives,” she said.

Steinbaum said the study also showed that you don’t have to go to the gym and follow a hard-core fitness regimen to reap benefits; just walking at a brisk pace — enough to get your heart rate up — is an option, too.

“It’s not hanging out and window shopping, but it’s a really nice walk and it can help with stress reduction. You can go outside with a friend and get your heart rate up for one hour and talk about life and laugh,” she said.

The researchers also looked at six studies on daily television watching in half a million people and found that watching for more than three hours a day was linked with an increased risk of death in all but the most active people. The death rate was significantly higher in people who watched TV for five hours or more a day.

Study author Ekelund added, “For many people who commute to work and have office-based jobs, there is no way to escape sitting for prolonged periods of time. For these people in particular, we cannot stress enough the importance of getting exercise, whether it’s getting out for a walk at lunchtime, going for a run in the morning or cycling to work. An hour of physical activity per day is the ideal, but if this is unmanageable, then at least doing some exercise each day can help reduce the risk.”

Source : http://www.cbsnews.com/news/one-hour-of-exercise-reverses-health-risks-of-sitting-all-day/

Ginger: Helpful or harmful for the stomach?

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Ingwertee

Ginger is one of the best-known remedies for relieving cold symptoms— it can actually kill the rhino virus that causes a cold. Plus, it’s been known to help with motion sickness and to calm an upset stomach. We checked in with our alternative medicine expert, The Medicine Hunter, for more:

“Ginger stimulates the production of bile and so as such it’s a beneficial digestive aid. But if you don’t have anything in your stomach— as it turns out this particular woman was drinking ginger tea on an empty stomach— it can sometimes cause… enough gastric stimulation that you can get some digestive distress,”  “It’s not a typical reaction. In fact, it’s rather uncommon, but it can happen.”

To avoid gastric upset while still getting anti-inflammatory benefits,  those with a sensitive digestive system have a bit of food in their stomachs and only drink modest amounts of ginger tea— one cup at a time.

Source : http://www.foxnews.com/health/2016/07/26/ginger-helpful-or-harmful-for-stomach.html

 

Blood clot deaths tied to hours of daily TV time

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TV

People who watch television for five or more hours a day have more than twice the risk of those who watch half as much TV to die of a blood clot in the lung, a large Japanese study suggests.

There are more than 200,000 cases of pulmonary embolism, which usually begins as a blood clot in the leg that travels to the lung, in the U.S. each year, according to the National Library of Medicine. It can permanently damage lung tissue, other organs, or cause death, but many people who have it have no symptoms.

Pulmonary embolism is less common in Japan than in Western countries, said study coauthor Dr. Hiroyasu Iso, professor of public health at Osaka University Graduate School of Medicine, but Japanese people are becoming increasingly sedentary.

“We were surprised about the strength of the effect of television watching compared with the effects of advancing age, history of hypertension and diabetes mellitus, or body mass index in this study,” Iso told Reuters Health by email. “We speculated that leg immobility during television watching had increased their risk of fatal pulmonary embolism.”

In a number of studies of long haul travelers, the association between prolonged sitting and increased risk of pulmonary embolism did not vary by ethnicity, Iso said.

Other past studies have looked back at the lifestyle factors common to pulmonary embolism cases, but none had followed people over time to see if there was a link between their TV-watching time and their risk for embolisms, the study team writes in Circulation.

Between 1988 and 1990 Iso and colleagues asked more than 85,000 adults 40 to 79 years old in Japan how many hours they spent watching TV, then followed them for the next 19 years looking for deaths from pulmonary embolism. They also collected information on obesity, diabetes, cigarette smoking and high blood pressure, and tried to rule these factors out in the relationship between TV and blood clots.

Only 59 people in the sample died of pulmonary embolism, but compared to people who watched two and a half hours of TV or less per day, those who watched five or more hours were 2.5 times as likely to die of a clot.

Researchers calculated that among people who watched less than two and a half hours of TV, the rate of deaths from pulmonary embolism were 2.8 per 100,000 people per year, compared to a rate of 8.2 deaths per 100,000 per year for those who watched five or more hours daily.

Risk of pulmonary embolism death increased by 40 percent for each additional two hours of daily TV watching, they found.

“Time spent watching TV is a pretty reliable way to measure how much time people spend sedentary, or inactive,” said Dr. Christopher Kabrhel, an Associate Professor of Emergency Medicine at Harvard Medical School in Boston who was not part of the new study. “If being sedentary puts you at risk for pulmonary embolism, and I believe it does, then it likely also puts you at risk of death from pulmonary embolism, as this study showed.”

After TV watching time, obesity was the next most important factor predicting risk of death from pulmonary embolism, the authors found.

Since U.S. adults watch more TV than Japanese adults, the results may be even more important to Americans, the authors said in a statement accompanying the study.

“Nowadays, with online video streaming, the term ‘binge-watching’ to describe viewing multiple episodes of television programs in one sitting has become popular,” lead author Dr. Toru Shirakawa, a research fellow in public health at Osaka University Graduate School of Medicine, wrote.

Travelers on long plane flights and people watching TV for long periods of time can stand up, stretch, walk around, or tense and relax their leg muscles for five minutes to reduce the risk of blood clots, they wrote.

“The results do not seem to be country-specific,” Kabrhel told Reuters Health by email. “Being sedentary is bad for you wherever you live.”

Source: http://www.foxnews.com/health/2016/07/27/blood-clot-deaths-tied-to-hours-daily-tv-time.html

Pomegranate finally reveals its powerful anti-aging secret

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Intestinal bacteria transform a molecule contained in the fruit with spectacular results

Are pomegranates really the superfood we’ve been led to believe will counteract the aging process? Up to now, scientific proof has been fairly weak. And some controversial marketing tactics have led to skepticism as well. A team of scientists from EPFL and the company Amazentis wanted to explore the issue by taking a closer look at the secrets of this plump pink fruit. They discovered that a molecule in pomegranates, transformed by microbes in the gut, enables muscle cells to protect themselves against one of the major causes of aging. In nematodes and rodents, the effect is nothing short of amazing. Human clinical trials are currently underway, but these initial findings have already been published in the journal Nature Medicine.

As we age, our cells increasingly struggle to recycle their powerhouses. Called mitochondria, these inner compartments are no longer able to carry out their vital function, thus accumulate in the cell. This degradation affects the health of many tissues, including muscles, which gradually weaken over the years. A buildup of dysfunctional mitochondria is also suspected of playing a role in other diseases of aging, such as Parkinson’s disease.

One molecule plays David against the Goliath of aging

The scientists identified a molecule that, all by itself, managed to re-establish the cell’s ability to recycle the components of the defective mitochondria: urolithin A. “It’s the only known molecule that can relaunch the mitochondrial clean-up process, otherwise known as mitophagy,” says Patrick Aebischer, co-author on the study. “It’s a completely natural substance, and its effect is powerful and measurable.”

The team started out by testing their hypothesis on the usual suspect: the nematode C. elegans. It’s a favorite test subject among aging experts, because after just 8-10 days it’s already considered elderly. The lifespan of worms exposed to urolithin A increased by more than 45% compared with the control group.

These initial encouraging results led the team to test the molecule on animals that have more in common with humans. In the rodent studies, like with C. elegans, a significant reduction in the number of mitochondria was observed, indicating that a robust cellular recycling process was taking place. Older mice, around two years of age, showed 42% better endurance while running than equally old mice in the control group.

Human testing underway

Before heading out to stock up on pomegranates, however, it’s worth noting that the fruit doesn’t itself contain the miracle molecule, but rather its precursor. That molecule is converted into urolithin A by the microbes that inhabit the intestine. Because of this, the amount of urolithin A produced can vary widely, depending on the species of animal and the flora present in the gut microbiome. Some individuals don’t produce any at all. If you’re one of the unlucky ones, it’s possible that pomegranate juice won’t do you any good.

For those without the right microbes in their guts, however, the scientists are already working on a solution. The study’s co-authors founded a start-up company, Amazentis, which has developed a method to deliver finely calibrated doses of urolithin A. The company is currently conducting first clinical trials testing the molecule in humans in European hospitals.

Darwin at your service: parallel evolution makes good dinner partners According to study co-author Johan Auwerx, it would be surprising if urolithin A weren’t effective in humans. “Species that are evolutionarily quite distant, such as C elegans and the rat, react to the same substance in the same way. That’s a good indication that we’re touching here on an essential mechanism in living organisms.”

Urolithin A’s function is the product of tens of millions of years of parallel evolution between plants, bacteria and animals. According to Chris Rinsch, co-author and CEO of Amazentis, this evolutionary process explains the molecule’s effectiveness: “Precursors to urolithin A are found not only in pomegranates, but also in smaller amounts in many nuts and berries. Yet for it to be produced in our intestines, the bacteria must be able to break down what we’re eating. When, via digestion, a substance is produced that is of benefit to us, natural selection favors both the bacteria involved and their host. Our objective is to follow strict clinical validations, so that everyone can benefit from the result of these millions of years of evolution.”

The EPFL scientists’ approach provides a whole new palette of opportunities to fight the muscular degeneration that takes place as we age, and possibly also to counteract other effects of aging. By helping the body to renew itself, urolithin A could well succeed where so many pharmaceutical products, most of which have tried to increase muscle mass, have failed. Auwerx, who has also published a recent discovery about the anti-aging effects of another molecule in the journal Science, emphasizes the game-changing importance of these studies. “The nutritional approach opens up territory that traditional pharma has never explored. It’s a true shift in the scientific paradigm.”

Source: http://bit.ly/29DRnHW

E-cigarettes impair immune responses more than tobacco

As evidence emerges that e-cigarettes are not as safe as advertisers claim, a new study shows that flavorings classed as “Generally Recognized as Safe” by the US Food and Drug Administration are best avoided in smoking. The findings are presented at the American Association for the Advancement of Science annual meeting in Washington, DC.

Cigarettes kill more than 480,000 people annually in the US. Since e-cigarettes appeared on the scene, many assume them to be a safer alternative, because smokers are not inhaling known carcinogens.

But as researchers analyze the contents of e-cigarettes, they are finding that some of them could be as risky as tobacco.

Ilona Jaspers, PhD, professor of pediatrics and director of the curriculum in toxicology at the University of North Carolina (UNC) School of Medicine has been researching new and emerging tobacco products, including e-cigarettes.

Having already found that cigarette smoking significantly impairs the immune responses of mucosal cells in the respiratory system, Jaspers’ lab is now looking at how e-cigarette chemicals affect immune responses in smokers’ airways.

E-cigarette flavorings not ‘recognized as safe’ for inhalation

While the Food and Drug Administration (FDA) may class e-cigarette flavorings “Generally Recognized as Safe,” Jaspers points out that this classification means they are safe for oral consumption.

But people do not consume e-cigarette flavorings orally, they inhale them. And the potential for toxic effects of inhalation have not been assessed, in most cases.

Researchers studied the effects on smokers of cinnamon-flavored e-liquids and cinnamaldehyde, the chemical that gives cinnamon flavor to an e-cigarette.

Results showed that the cinnamaldehyde e-liquids had a significant negative impact on epithelial cells that could set off a chain of cellular mechanisms potentially leading to impaired immune responses in the lung.

Jaspers elaborates: “The chemicals compromise the immune function of key respiratory immune cells, such as macrophages, natural killer cells and neutrophils.”

Source: medical news today

Water births ‘pose no extra risk’

Birthing pools have been used for some time in Europe, Australia and New Zealand. In the US, they have gained popularity. However, safety concerns have caused controversy.

Immersion in water during labor is thought to have various benefits, including less need for pain medication and, theoretically, a smaller chance of vaginal trauma, as the perineum becomes more elastic and relaxed in water.

The water is believed to reduce stress hormones and decrease blood pressure, easing tension in the mother. For the baby to pass from the amniotic sac into the warm water may also be less stressful for the neonate, possibly reducing fetal complications.

One concern is the possibility of drowning. When babies are born, they have a “dive reflex,” which means they can block their throats when underwater. This should mean there is little chance of drowning. However, near-drownings have been reported due to the baby breathing in fluid from the tub.

There is also a small risk that water will enter the mother’s bloodstream, causing a water embolism. The fear of additional exposure to infection has also been voiced, although at least one study has indicated that this is unlikely.

The American College of Obstetricians and Gynecologists and the American Academy of Pediatrics support laboring in water but not being immersed when the baby is born.

Researchers at Oregon State University (OSU) studied data on nearly 17,000 women who gave birth in the US between 2004-2009. The majority were attended by Certified Professional Midwives.

The source of the data was the Midwives Alliance of North America Statistics Project (MANA Stats), and the midwives provided detailed reports on their cases from their medical records.

Of the 17,000 recorded cases, more than 6,500 of the deliveries were water births. These births were all attended by midwives, and they all took place either in a dedicated birthing center or at home. None of the water births analyzed were carried out in a hospital.

Source: medical news today