5 Ways to Beat the Winter Blues

Call it the winter blues or blahs or simply seasonal sadness. Whatever term you use, around this time, many of us start to feel our mood sinking. We feel especially tired and sluggish. We might even feel like the walking dead, moping from one task to the next.

That’s because as the days get shorter and colder, we spend more time indoors and are less active, according to Ashley Solomon, PsyD, a clinical psychologist who blogs at Nourishing the Soul. “We tend to be more sedentary, which we know impacts our level of energy and even interest in activities,” she said.

It also doesn’t help that our bodies produce more melatonin when the sun sets, making us sleepy, said Deborah Serani, Psy.D, a clinical psychologist and author of the book Living with Depression. (Interestingly, melatonin is known as “the Dracula of hormones,” because it only comes out at night, according to the National SleepFoundation.)

Our eating habits also contribute to our sinking mood and energy levels. “We tend to eat warmer, heartier meals because that’s part of our evolutionary survival strategy for staying protected through the winter months,” Solomon said. Eating more sugary foods – which is common from Halloween to New Year’s – also spikes glucose levels, leading to a crash of exhaustion, Serani said.

But that doesn’t mean you’re doomed to a dull and fatigued fall and winter. Here are five ways to lift your energy and mood.

1. Better understand your body clock.

For some of us seasonal changes have a dramatic effect on our bodies. For others, it’s a subtle shift, if there’s one at all. This has to do with our circadian rhythms.

Our circadian rhythm is essentially an internal body clock. “[It] regulates our body with respect to sleeping, feeding and well-being,” Serani said. Circadian rhythms respond to sunlight. With less sun exposure in the fall and winter, many people experience a shift in their circadian rhythm, she said.

How can you tell if you’ve been affected? If you’re sluggish during the times of the day you used to feel energetic or you’re exhausted when you used to be well rested, the seasonal changes might be affecting you, she said.

To reset your clock, on the weekends, when possible, wake up without an alarm so your body gets adequate rest, Serani said. For some, melatonin supplements might improve sleep, she said.

Getting enough sunshine is key. Twenty minutes a day seems to be the magic number, Serani said. You can achieve that by going outside or soaking in the sunshine by a window, she said. Or you can buy a light box, which emits bright artificial light.

(Light therapy is actually very helpful for people with seasonal affective disorder, a form of clinical depression that occurs during the winter. This New York Times article has some good information.)

2. Keep up regular physical activity.

Depending on where you live, you might want to participate in winter activities, such as skiing, snowboarding, snowshoeing, ice-skating or hockey.

But if those aren’t appealing, Solomon said, “even taking a short walk each day or going to an indoor yoga class can help.” Workout DVDs are another option.

If you’re not sure what you like, try a variety of activities that sound like fun. Then pay attention to which activities boost your mood and energy levels.

3. Eat a variety of foods. 

“Make sure you’re eating a variety of foods, including as many fruits and vegetables as you can,” Solomon said. If fresh produce isn’t available, eat foods that are in season, she said.

Also, “Though the colder weather makes us crave sweets and starches, be mindful to keep protein in your diet as a balance,” Serani said. “Protein doesn’t spike your sugar levels, leaving you to feel more satisfied, less irritable and tired than simple carbohydrates and sugars.”

Keep in mind that this isn’t about restricting what you eat or feeling ashamed – or sinful – about eating sugar. (There’s nothing criminal about savoring your favorite desserts.) Rather, it’s about paying attention to how foods affect you, giving your body the nutrients it needs and enjoying what you eat.

4. Socialize.

As the temps take a nosedive, the last thing you might want to do is leave your house. But try. “Schedule regular contact with friends and family, even if it’s via Skype,” Solomon said. Still, make sure you’re also getting out, she stressed.

5. Pamper yourself.

When you think of treating yourself, what comes to mind? For instance, consider taking fragrant baths, drinking hot tea, reading books, lighting candles or cuddling with a loved one, said Serani, who tends to pamper herself more during the fall and wintertime. “These seasonal things raise dopamine, serotonin and oxytocin, feel-good hormones that improve mood,” she said.

Source: Psychentral.com


Syphilis’ (Sexually Transmitted Infection) origins still unknown

Researchers have said that despite trying to find the origins of the sexually transmitted infection syphilis they have come up with an empty hand.

According to the “Columbian” theory, Christopher Columbus’ crews brought the infection from America to Europe while returning home in 1492 and the first recorded epidemic of syphilis occurred, during the French invasion of the Italian city of Naples in 1495.

However, critic’s claim that the disease may have been present in Europe before Columbus’ return, and it just wasn’t distinguished from other conditions like leprosy until 1495, LiveScience reported.

Syphilis is capable of damaging heart, brain, eyes and bones, and can even be fatal if left untreated.

The first mention of the disease appears in the historical record in the 1496 writings of a man who went by the name Joseph Grnpeck.

However, Italian physician and poet Girolamo Fracastoro was the first man to use the word “syphilis” in 1530 in a Latin poem.

The study has been published in the Journal of Sexual Medicine.

Source: Yahoo News


Blame your genes for your aging brain

Senior author John Blangero, Ph.D., a Texas Biomed geneticist, said that identification of genes associated with brain aging should improve our understanding of the biological processes that govern normal age-related decline.

In large pedigrees including 1,129 people aged 18 to 83, the scientists documented profound aging effects from young adulthood to old age, on neurocognitive ability and brain white matter measures. White matter actively affects how the brain learns and functions.

Genetic material shared amongst biological relatives appears to predict the observed changes in brain function with age.

Blangero said that the use of large human pedigrees provides a powerful resource for measuring how genetic factors change with age.

By applying a sophisticated analysis, the scientists demonstrated a heritable basis for neurocognitive deterioration with age that could be attributed to genetic factors. Similarly, decreasing white matter integrity with age was influenced by genes.

The investigators further demonstrated that different sets of genes are responsible for these two biological aging processes

Source: Newstrackindia


Hair regeneration method uses patient’s own cells to grow new hair

Researchers at Columbia University Medical Center (CUMC) have devised a hair restoration method that can generate new human hair growth, rather than simply redistribute hair from one part of the scalp to another. The approach could significantly expand the use of hair transplantation to women with hair loss, who tend to have insufficient donor hair, as well as to men in early stages of baldness. The study was published today in the online edition of the Proceedings of the National Academy of Sciences (PNAS).

“About 90 percent of women with hair loss are not strong candidates for hair transplantation surgery because of insufficient donor hair,” said co-study leader Angela M. Christiano, PhD, the Richard and Mildred Rhodebeck Professor of Dermatology and professor of genetics & development. “This method offers the possibility of inducing large numbers of hair follicles or rejuvenating existing hair follicles, starting with cells grown from just a few hundred donor hairs. It could make hair transplantation available to individuals with a limited number of follicles, including those with female-pattern hair loss, scarring alopecia, and hair loss due to burns.”

According to Dr. Christiano, such patients gain little benefit from existing hair-loss medications, which tend to slow the rate of hair loss but usually do not stimulate robust new hair growth.

“Dermal papilla cells give rise to hair follicles, and the notion of cloning hair follicles using inductive dermal papilla cells has been around for 40 years or so,” said co-study leader Colin Jahoda, PhD, professor of stem cell sciences at Durham University, England, and co-director of North East England Stem Cell Institute, who is one of the early founders of the field.  “However, once the dermal papilla cells are put into conventional, two-dimensional tissue culture, they revert to basic skin cells and lose their ability to produce hair follicles.  So we were faced with a Catch-22: how to expand a sufficiently large number of cells for hair regeneration while retaining their inductive properties.”

The researchers found a clue to overcoming this barrier in their observations of rodent hair.  Rodent papillae can be easily harvested, expanded, and successfully transplanted back into rodent skin, a method pioneered by Dr. Jahoda several years ago. The main reason that rodent hair is readily transplantable, the researchers suspected, is that their dermal papillae (unlike human papillae) tend to spontaneously aggregate, or form clumps, in tissue culture. The team reasoned that these aggregations must create their own extracellular environment, which allows the papillae to interact and release signals that ultimately reprogram the recipient skin to grow new follicles.

“This suggested that if we cultured human papillae in such a way as to encourage them to aggregate the way rodent cells do spontaneously, it could create the conditions needed to induce hair growth in human skin,” said first author Claire A. Higgins, PhD, associate research scientist.

To test their hypothesis, the researchers harvested dermal papillae from seven human donors and cloned the cells in tissue culture; no additional growth factors were added to the cultures. After a few days, the cultured papillae were transplanted between the dermis and epidermis of human skin that had been grafted onto the backs of mice. In five of the seven tests, the transplants resulted in new hair growth that lasted at least six weeks. DNA analysis confirmed that the new hair follicles were human and genetically matched the donors.

“This approach has the potential to transform the medical treatment of hair loss,” said Dr. Christiano. “Current hair-loss medications tend to slow the loss of hair follicles or potentially stimulate the growth of existing hairs, but they do not create new hair follicles. Neither do conventional hair transplants, which relocate a set number of hairs from the back of the scalp to the front. Our method, in contrast, has the potential to actually grow new follicles using a patient’s own cells. This could greatly expand the utility of hair restoration surgery to women and to younger patients—now it is largely restricted to the treatment of male-pattern baldness in patients with stable disease.”

More work needs to be done before the method can be tested in humans, according to the researchers. “We need to establish the origins of the critical intrinsic properties of the newly induced hairs, such as their hair cycle kinetics, color, angle, positioning, and texture” said Dr. Jahoda. “We also need to establish the role of the host epidermal cells that the dermal papilla cells interact with, to make the new structures.”  The team is optimistic that clinical trials could begin in the near future. “We also think that this study is an important step toward the goal of creating a replacement skin that contains hair follicles for use with, for example, burn patients,” said Dr Jahoda.

The researchers used gene expression analyses to determine that the three-dimensional cultures restored 22 percent of the gene expression seen in normal hair follicles. “That’s less than we expected, but it was sufficient for inducing the growth of new hair follicles,” said Dr. Christiano.

In addition, using methods for the analysis of regulatory networks developed by the Califano lab in the Center for Computational Biology and Bioinformatics, Department of Systems Biology, the researchers identified a number of transcription factors (gene regulators) that have the potential to mimic the environmental signals that trigger papillae to induce new hair growth. This information could help researchers develop ways to restore the expression of more genes involved in hair growth and to increase the efficiency of the induction.

The paper is titled, “Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair follicle growth.” The other contributors are James C. Chen and Jane E. Cerise, both at CUMC.

The study was supported by a Science of Human Appearance Career Development Award from the Dermatology Foundation and by grants from the Medical Research Council of the UK, the Empire State Development’s Division of Science, Technology and Innovation (NYSTAR), New York Stem Cell Science (NYSTEM), and the Biotechnology and Biological Sciences Research Council in the UK (BBSRC), as well as earlier support from the Steven and Michele Kirsch Foundation. Dr. Christiano is a member of the Columbia Stem Cell Initiative. The authors declare no financial or other conflicts of interests.

Source: Newsroom.columbia.edu


Cancer vaccine developed to boost lifespan of patients

Russian scientists have developed a vaccine for the treatment of cancer that can increase the patient’s lifespan more than two-fold, ITAR-TASS reported on Wednesday.

The vaccine, developed at the Institute of Clinical Immunology in the Siberian branch of the Russian Academy of Medical Sciences in Novosibirsk, has already successfully passed clinical tests, said institute’s director Vladimir Kozlov.

Currently, it is being administered to patients by injection at the third and fourth stages of cancer.

”We are deriving dendritic cells from the human body and loading them with tumor antigens,” Kozlov said.

“Dendritic cells process them, then we inject the cells into the patient and they start working in the body evoking a strong immune response. That is, they are actively fighting the tumor.”

The institute’s creation “is not a classical vaccine, which is the means to prevent the illness”, Kozlov said. “In fact, it is a cell therapy.”

The vaccine is counteracting several types of cancer – colorectal (bowel) cancer, breast cancer and prostate cancer – and the institute is ready to start its industrial production, Kozlov added.

However, the scientist added that other types of therapy were to be used as well, such as chemotherapy and radiation therapy.

Source: Khaleej Times


Apollo Hospitals launches web-based Personal Health Record

Hyderabad: Apollo Hospitals, in association with HealthHiway, on Tuesday launched Apollo Prism, a web-based personal health record (PHR) that would enable patients to receive, create and manage their health information such as lab test results, discharge summary, medical history, medications and other health interventions. The patients can then choose to share all or part of their health information with their loved ones and Apollo hospital.

Apollo Prism has been launched across all Apollo Hospitals locations. It has been tightly integrated with the hospital information system across locations, thus providing clinically validated information to patients, who come to Apollo Hospitals. Information is entirely patient controlled and completely confidential. Patients can also download the mobile application of Apollo Prism that lets them receive their lab test results on their phone. Apollo Prism is also an interface for diabetic patients, for managing their diabetes. Thus, beyond helping a patient to track and manage their health information, the PHR enables continuous, preventive and wellness support, according to a statement by Apollo Hospitals.

Sangita Reddy, executive director, Apollo Hospitals, said, “Apollo Prism is a significant step forward in our mission to further engage, involve and create a more delightful experience for our patients. When our patients have easy and secure access to their medical information, it reduces costs, improves outcomes and enables superior care.”

Madhu Aravind, CEO, HealthHiway, said, “Traditionally, care provided by a hospital was inward focused and physician centric. A PHR is a first step in involving and engaging the patient and makes the care delivery centered on the needs of the patient.”

Headquartered in Bangalore, HealthHiway is a cloud-based health information network that enables seamless exchange of health information – data sharing and transactional – between hospitals, clinics, diagnostics, insurers, doctors and patients.

Source: Indian Medical Times


Open-heart surgery gives new lease of life to 5-day-old baby

A five-day-old baby with G6PD deficiency – a disorder caused by an abnormal X-chromosome gene, successfully underwent a complex open-heart surgery recently.

According to medical literature, till date, only two paediatric cardiac cases were associated with the disorders have been successfully treated.

Dr Vijay Agarwal, chief paediatric cardiac surgeon, at Fortis Hospital, said, “The child had turned blue due to lack of oxygen supply in his body. His tests showed that he had transposition of great arteries that required immediate surgery if we want to save him.”

Luckily, Dr Agarwal said the hospital where the child was born had done a battery of tests as a part of their routine which revealed that he was suffering from G6PD.

“It was a crucial piece of information that helped us in taking the right measures. In G6PD patients, you have to avoid certain medications that may lead to heavy bleeding and death.
Therefore, it was the biggest challenge in front us,” said Dr Agarwal.

Dr Agarwal added that apart from the G6PD disorder the child also had a single coronary artery instead of two. “Usually in open-heart surgery we need to cool the child below 30 degree Celsius to protect his organs. In his case, it was not possible as that would have led to severe bleeding because of his disorder,” said Dr Agarwal.

Taking help of medical literature, the team of doctors took measures for all possible risk associated with the surgery. The surgery lasted for seven hours. “We avoided the general drugs used in anaesthesia. We maintained the cooling temperature at 33 degree Celsius. Luckily, everything fell in place and the operation was successful. The child had an unusual combination of problems. Moreover, the child weighed only 2.4kg and had jaundice at birth. He has still managed to survive and we are happy that he is now fit to be discharged,” said Dr Agarwal. The team of doctors will be presenting the case in international conferences because of its uniqueness.

Source: http://bit.ly/1doePCr


Protein-rich diet can help cut rebound weight gain

Researchers have found that a diet rich in protein and meal replacements can help people, who have lost weight after a successful diet, keep off the kilos.

Research team member Dr Erik Hemmingsson said that the body has several defense mechanisms against weight loss, such as increased hunger, lower energy metabolism and relapse back to old habits.

In their meta-analysis, the team from Karolinska University Hospital combined the results of 20 published scientific studies, including a total of 3,017 participants, who were either obese or overweight at the start of the weight loss process.

The various studies examined the effects of drugs, meal replacements, high protein diets, dietary supplements and exercise on rebound weight gain after an intensive weight loss, low-calorie diet (less the 1,000 calories a day).

Even though the study shows that rebound weight gain is more the rule than the exception, the researchers found that several strategies helped to reduce the unwanted effect: powdered meal replacements and a high protein diet.

The study is published in the American Journal of Clinical Nutrition.

Source: http://bit.ly/1740ExJ


Long-term use of painkillers can lead to depression

Researchers have found that people who have been using pain-relieving medications, like Opioid analgesics, for a longtime are at higher risk of developing depression.

The study analyzed medical record data of about 50,000 veterans, who had no history of opioid use or depression, and were subsequently prescribed opioid pain killers.

According to the findings, patients who started and remained on opioids for 180 days or longer were at a 53 percent increased risk of developing a new episode of depression, and those using opioids for 90-180 days were at a 25 percent increased risk compared to patients who never took opioids for longer than 1-89 days.

Jeffrey Scherrer, associate professor at Saint Louis University and principle investigator of the study, said that the findings suggest that the longer one is exposed to opioid analgesics, the greater is their risk of developing depression.

The study also suggests that the higher the dose of opioid analgesics, the greater the risk of depression.

The study is published in the Journal of General Internal Medicine.

Source; http://bit.ly/1740syB


Chinese vaccine to save Asian children from encephalitis gets WHO nod

China’s first vaccine to save children in Asia from deadly Japanese encephalitis has been approved for global use by the World Health Organization.

The vaccine, manufactured by the Chengdu Institute of Biological Products, has received WHO prequalification, which means it meets international standards for quality, safety and efficacy.

According to China Daily, WHO Director-General Margaret Chan said that the move from China, which is producing vaccines up to WHO standards, is a welcome development, both in the fight to protect children in developing countries from the virus and in the future availability of vaccines more generally.

She said that there is a huge potential for vaccine manufacture in China, adding that she hopes to see more Chinese vaccines get WHO prequalification. The whole world will benefit.

The GAVI Alliance, a public-private global health partnership committed to saving children and increasing access to immunization in poor countries, said it is preparing to make funding available for the vaccine, the report said.

CEO Seth Berkley said that the Chinese vaccine industry has huge potential to benefit children in the poorest countries by offering secure, predictable supply at affordable prices, the report added.

The GAVI Alliance brings together governments, the WHO, UNICEF, the World Bank, vaccine industries in industrialized and developing countries, research and technical agencies and civil societies and the Bill and Melinda Gates Foundation and other private philanthropists.

Japanese encephalitis is a vicious illness that strikes quickly and usually has a devastating impact on children and their families, Berkley said.

Source: http://bit.ly/HGM7S2